41318-75-6

Usage

Uses

Used in Electronics Industry:
2,4,4'-Tribromodiphenyl ether is used as a flame retardant in electronic devices to reduce the risk of fire and improve safety. Its hydrophobic properties and ability to accumulate in materials make it an effective fire retardant, protecting electronic components from potential damage caused by heat or flames.
Used in Textile Industry:
In the textile industry, 2,4,4'-Tribromodiphenyl ether is used as a flame retardant in fabrics and textiles to enhance their fire resistance. This is particularly important for products such as upholstery, carpets, and curtains, where fire safety is a critical concern.
Used in Plastics Industry:
2,4,4'-Tribromodiphenyl ether is also used as a flame retardant in the production of various types of plastics. Its incorporation into plastic materials helps to reduce the risk of fire and improve the overall safety of plastic products, especially those used in high-risk environments or applications.
However, it is important to note that due to the potential health risks and environmental concerns associated with BDE-28, many countries have restricted or banned its use in consumer products. As a result, the demand for safer and more environmentally friendly flame retardants has increased, leading to the development of alternative compounds and technologies.

InChI:InChI=1/C12H7Br3O/c13-8-1-4-10(5-2-8)16-12-6-3-9(14)7-11(12)15/h1-7H

Upstream product

• 101-84-8 diphenylether 
• 615-58-7 2,4-dibromophenol 
• 53601-22-2 4,4'-dibromodiphenyliodonium chloride 
• 106-41-2 4-bromo-phenol 
• 108-86-1 bromobenzene 
• 108-36-1 1,3-dibromobenzene 

Downstream Products

• 41318-52-9 2,4-Bis-trimethylsilanyl-1-(4-trimethylsilanyl-phenoxy)-benzene 

Relevant academic research and scientific papers

Synthesis of polybrominated diphenyl ethers and their capacity to induce CYP1A by the Ah receptor mediated pathway

Polybrominated diphenyl ethers (PBDEs) have become widely distributed as environmental contaminants due to their use as flame retardants. Their structural similarity to other halogenated aromatic pollutants has led to speculation that they might share toxicological properties such as hepatic enzyme induction. In this work we synthesized a number of PBDE congeners, studied their affinity for rat hepatic Ah receptor through competitive binding assays, and determined their ability to induce hepatic cytochrome P-450 enzymes by means of EROD (ethoxyre-sorufin-O-deethylase) assays in human, rat, chick, and rainbow trout cells. Both pure PBDE congeners and commercial PBDE mixtures had Ah receptor binding affinities 10-2-10-5 times that of 2,3,7,8-tetrachlorodibenzo-p-dioxin. In contrast with polychlorinated biphenyls, Ah receptor binding affinities of PBDEs could not be related to the planarity of the molecule, possibly because the large size of the bromine atoms expands the Ah receptor's binding site. EROD activities of the PBDE congeners followed a similar rank order in all cells. Some congeners, notably PBDE 85, did not follow the usual trend in which strength of Ah receptor binding affinity paralleled P-450 induction potency. Use of the gel retardation assay with a synthetic oligonucleotide indicated that in these cases the liganded Ah receptor failed to bind to the DNA recognition sequence.

Synthesis and characterization of 32 polybrominated diphenyl ethers

Polybrominated diphenyl ethers (PBDEs) are widely used as additive flame retardants in, for example, textiles, computers, television sets, and other electrical appliances. present also in humans. The environmental levels of the PBDEs are, however, still in general lower than those of polychlorinated biphenyls (PCBs). However, while the levels of PCBs generally are decreasing, those of the PBDEs are increasing in, for example, human milk. In the present study 32 individual PBDE congeners were synthesized and characterized. Physicochemical parameters including melting points and UV, 1H NMR, and mass spectra are reported Twenty-nine monobrominated to heptabrominated diphenyl ethers were synthesized by the couping between four diphenyliodonium salts and nine phenolates. One tetrabromodiphenyl ether and two hexabromodiphenyl ethers were synthesized by bromination of two different PBDEs. Twenty-one of the PBDEs and two of the iodonium salts, 2,2′,4,4′-tetrabromodiphenyliodonium chloride and 3,3′,4,4′-tatrabromodiphenyliodonium chloride, are to the authors' knowledge described for the first time. These synthesized reference compounds will aid in the identification and quantification of PBDEs present in environmental samples and will allow further assessment of PBDE toxicity.