41318-75-6

Basic information

• Product Name: 2,4,4'-TRIBROMODIPHENYL ETHER
• Synonyms: BDE-28;2,4,4'-TRIBROMODIPHENYL ETHER;2,4,4μ-TriBDE, 2,4,4μ-Tribromodiphenyl ether solution, PBDE 28;BDE No 28 solution;2,4,4’Tribromodiphenyl ether,50 μL/mL in Isooctane;Benzene, 2,4-dibromo-1-(4-bromophenoxy)-;2,4,4′-TriBDE;2,4-Dibromo-1-(4-bromophenoxy)benzene
• CAS NO: 41318-75-6
• Molecular Formula: C₁₂H₇Br₃O
• Molecular Weight: 406.89538
• EINECS: 208-759-1
• Mol File: 41318-75-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 370.654°C at 760 mmHg
• Flash Point: -12 °C
• Appearance: /
• Density: 1.951g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,4,4'-TRIBROMODIPHENYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,4'-TRIBROMODIPHENYL ETHER(41318-75-6)
• EPA Substance Registry System: 2,4,4'-TRIBROMODIPHENYL ETHER(41318-75-6)

Safety Data

• Hazard Codes: F,Xn,N
• Statements: 11-38-50/53-65-67
• Safety Statements: 60-61-62-33-29-16-9
• RIDADR: UN 1262 3/PG 2
• WGK Germany: 2
• Hazardous Substances Data: 41318-75-6(Hazardous Substances Data)

Usage

General Description

2,4,4'-Tribromodiphenyl ether, also known as BDE-28, is a member of the polybrominated diphenyl ether (PBDE) family of flame retardant chemicals. It is a white crystalline solid that is hydrophobic and can accumulate in the environment and living organisms. BDE-28 is used as a flame retardant in various consumer products such as electronics, textiles, and plastics. However, it has been found to be persistent, bioaccumulative, and toxic, and has been linked to a range of adverse health effects, including disruption of thyroid hormone function and neurodevelopmental toxicity. As a result, many countries have restricted or banned the use of BDE-28 and other PBDEs in consumer products.

InChI:InChI=1/C12H7Br3O/c13-8-1-4-10(5-2-8)16-12-6-3-9(14)7-11(12)15/h1-7H

Upstream product

• 106-41-2 4-bromo-phenol 
• 108-36-1 1,3-dibromobenzene 
• 108-86-1 bromobenzene 
• 615-58-7 2,4-dibromophenol 
• 53601-22-2 4,4'-dibromodiphenyliodonium chloride 
• 101-84-8 diphenylether 

Downstream Products

• 41318-52-9 2,4-Bis-trimethylsilanyl-1-(4-trimethylsilanyl-phenoxy)-benzene 

Relevant articles and documents

Synthesis of polybrominated diphenyl ethers and their capacity to induce CYP1A by the Ah receptor mediated pathway

Polybrominated diphenyl ethers (PBDEs) have become widely distributed as environmental contaminants due to their use as flame retardants. Their structural similarity to other halogenated aromatic pollutants has led to speculation that they might share toxicological properties such as hepatic enzyme induction. In this work we synthesized a number of PBDE congeners, studied their affinity for rat hepatic Ah receptor through competitive binding assays, and determined their ability to induce hepatic cytochrome P-450 enzymes by means of EROD (ethoxyre-sorufin-O-deethylase) assays in human, rat, chick, and rainbow trout cells. Both pure PBDE congeners and commercial PBDE mixtures had Ah receptor binding affinities 10-2-10-5 times that of 2,3,7,8-tetrachlorodibenzo-p-dioxin. In contrast with polychlorinated biphenyls, Ah receptor binding affinities of PBDEs could not be related to the planarity of the molecule, possibly because the large size of the bromine atoms expands the Ah receptor's binding site. EROD activities of the PBDE congeners followed a similar rank order in all cells. Some congeners, notably PBDE 85, did not follow the usual trend in which strength of Ah receptor binding affinity paralleled P-450 induction potency. Use of the gel retardation assay with a synthetic oligonucleotide indicated that in these cases the liganded Ah receptor failed to bind to the DNA recognition sequence.