41335-47-1Relevant academic research and scientific papers
A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms
Carradori, Simone,Secci, Daniela,De Monte, Celeste,Mollica, Adriano,Ceruso, Mariangela,Akdemir, Atilla,Sobolev, Anatoly P.,Codispoti, Rossella,De Cosmi, Federica,Guglielmi, Paolo,Supuran, Claudiu T.
, p. 1095 - 1105 (2016)
Small libraries of N-substituted saccharin and N-/O-substituted acesulfame derivatives were synthesized and tested as atypical and selective inhibitors of four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). Most of the
Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms
D'ascenzio, Melissa,Guglielmi, Paolo,Secci, Daniela,Carradori, Simone,Florio, Rosalba,Mollica, Adriano,Ceruso, Mariangela,Supuran, Claudiu T.,Akdemir, Atilla,Sobolev, Anatoly P.
, p. 51 - 59 (2017/11/08)
A large number of novel secondary sulfonamides based on the open saccharin scaffold were synthesized and evaluated as selective inhibitors of four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). They were obtained by re
Metal-free, highly efficient organocatalytic amination of benzylic C-H bonds
Xue, Qicai,Xie, Jin,Li, Huamin,Cheng, Yixiang,Zhu, Chengjian
supporting information, p. 3700 - 3702 (2013/05/09)
A new synthetic approach toward direct C-N bond formation through sp 3 C-H activation has been developed under metal-free conditions. Both primary and secondary benzylic C-H substrates could react smoothly with various amines to give only mono-amination products with good to excellent yields. The Royal Society of Chemistry 2013.
Intermolecular oxidative C-N bond formation under metal-free conditions: Control of chemoselectivity between aryl sp2 and benzylic sp 3 C-H bond imidation
Kim, Hyun Jin,Kim, Jiyu,Cho, Seung Hwan,Chang, Sukbok
supporting information; experimental part, p. 16382 - 16385 (2011/12/13)
A new synthetic approach toward intermolecular oxidative C-N bond formation of arenes has been developed under transition-metal-free conditions. Complete control of chemoselectivity between aryl sp2 and benzylic sp 3 C-H bond imidation was achieved by the choice of nitrogen sources, representatively being phthalimide and dibenzenesulfonimide, respectively.
