41373-90-4

Basic information

• Product Name: 4-PHENYL-3,6-PYRIDAZINEDIOL
• Synonyms: 4-PHENYL-3,6-PYRIDAZINEDIOL;3(2H)-Pyridazinone, 6-hydroxy-4-phenyl-;4-phenylpyridazine-3,6-diol;4-Phenyl-1,2-dihydro-3,6-pyridazinedione
• CAS NO: 41373-90-4
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.185
• Mol File: 41373-90-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Density: 1.28g/cm³
• Refractive Index: 1.588
• CAS DataBase Reference: 4-PHENYL-3,6-PYRIDAZINEDIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYL-3,6-PYRIDAZINEDIOL(41373-90-4)
• EPA Substance Registry System: 4-PHENYL-3,6-PYRIDAZINEDIOL(41373-90-4)

Safety Data

• Hazardous Substances Data: 41373-90-4(Hazardous Substances Data)

Usage

General Description

4-PHENYL-3,6-PYRIDAZINEDIOL, also known as KMD-3213, is a chemical compound that belongs to the pyridazin-3(2H)-one family. It is a novel drug candidate with potential antitumor and anticancer properties. Studies have shown that 4-PHENYL-3,6-PYRIDAZINEDIOL has a high degree of selectivity towards cancer cells, making it a promising option for cancer treatment. It functions by inhibiting the activity of certain enzymes which are involved in cancer cell proliferation and survival. Additionally, it has demonstrated low toxicity in preclinical studies, suggesting that it may have a favorable safety profile for use in humans. Further research and clinical trials are needed to fully understand the therapeutic potential of 4-PHENYL-3,6-PYRIDAZINEDIOL in cancer treatment.

InChI:InChI=1/C10H8N2O2/c13-9-6-8(10(14)12-11-9)7-4-2-1-3-5-7/h1-6H,(H,11,13)(H,12,14)

Upstream product

• 36122-35-7 2-phenylmaleic anhydride 
• 16110-98-8 (Z)-2-phenylbut-2-enedioic acid 
• 591-50-4 iodobenzene 

Downstream Products

• 869487-49-0 6-chloro-5-phenyl-3-pyridazinylhydrazine 
• 54248-83-8 6-chloro-7-phenyl-[1,2,4]triazolo[4,3-b]pyridazine 
• 54248-86-1 3-methyl-7-phenyl-[1,2,4]triazolo[4,3-b]pyridazine-6-ylchloride 
• 54248-88-3 3,7-diphenyl-[1,2,4]triazolo[4,3-b]pyridazine-6-ylchloride 
• 1357263-06-9 6-chloro-2-methyl-7-phenyl-imidazo[1,2-b]pyridazine 
• 54248-74-7 6-chloro-8-phenyl-imidazo[1,2-b]pyridazine 
• 881209-27-4 6-chloro-5-phenyl-pyridazin-3-yl-amine 
• 944468-99-9 6-chloro-4-phenyl-pyridazin-3-yl-amine 

Relevant articles and documents

Pyridazinone derivative and application thereof

The invention provides a pyridazinone derivative and an application thereof, the pyridazinone derivative with the structure shown in the formula (I) provided by the invention has good activity as a thyroid hormone beta receptor agonist by selecting a specific modification group. The compound can be used for treating and/or preventing diseases caused by thyroid hormone regulation.

SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES

The invention relates to imidazo[1,2-b]pyridazines of general formula (I) a process for their manufacuture and their use for the treatment of benign and malignant neoplasia.

SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE

The present invention relates to pyridines, pyrimidines and derivatives thereof, and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic beta cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.