41377-52-0

Basic information

• Product Name: N'-(5-bromo-2-hydroxybenzylidene)nicotinohydrazide
• Synonyms: N'-(5-bromo-2-hydroxybenzylidene)nicotinohydrazide
• CAS NO: 41377-52-0
• Molecular Weight: 320.145
• Mol File: 41377-52-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N'-(5-bromo-2-hydroxybenzylidene)nicotinohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-(5-bromo-2-hydroxybenzylidene)nicotinohydrazide(41377-52-0)
• EPA Substance Registry System: N'-(5-bromo-2-hydroxybenzylidene)nicotinohydrazide(41377-52-0)

Safety Data

• Hazardous Substances Data: 41377-52-0(Hazardous Substances Data)

Upstream product

• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 553-53-7 Nicotinic acid hydrazide 
• 1761-61-1 5-bromosalicyclaldehyde 
• 59-67-6 nicotinic acid 

Relevant articles and documents

Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the

Synthesis, characterization, crystal structures, Hirshfeld surface analysis, DFT computational studies and catalytic activity of novel oxovanadium and dioxomolybdenum complexes with ONO tridentate Schiff base ligand

For the first time, two new oxovanadium and dioxomolybdenum Schiff base complexes, VOL(OMe) and MoO2L, were synthesized through the reaction of a ONO tridentate Schiff base ligand (H2L) derived from the condensation of 5-bromosalicyl

Potent antimicrobial agents against azole-resistant fungi based on pyridinohydrazide and hydrazomethylpyridine structural motifs

Abstract Schiff base derivatives have recently been shown to possess antimicrobial activity, and these derivatives include a limited number of salicylaldehyde hydrazones. To further explore this structure-activity relationship between salicylaldehyde hydrazones and antifungal activity, we previously synthesized and analyzed a large series of salicylaldehyde and formylpyridinetrione hydrazones for their ability to inhibit fungal growth of both azole-susceptible and azole-resistant species of Candida. While many of these analogs showed excellent growth inhibition with low mammalian cell toxicity, their activity did not extend to azole-resistant species of Candida. To further dissect the structural features necessary to inhibit azole-resistant fungal species, we synthesized a new class of modified salicylaldehyde derivatives and subsequently identified a series of modified pyridine-based hydrazones that had potent fungicidal antifungal activity against multiple Candida spp. Here we would like to present our synthetic procedures as well as the results from fungal growth inhibition assays, mammalian cell toxicity assays, time-kill assays and synergy studies of these novel pyridine-based hydrazones on both azole-susceptible and azole-resistant fungal species.