41402-58-8Relevant academic research and scientific papers
MODULATORS OF TMEM16A FOR TREATING RESPIRATORY DISEASE
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Page/Page column 62, (2020/12/30)
Compounds of general formula (I), which are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A. wherein A is defined as Formula.
BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS
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Page/Page column 234; 255, (2017/05/02)
Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.
POTENT DUAL BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS
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Page/Page column 122; 142-143, (2016/04/26)
Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.
Copper-catalyzed synthesis of benzoxazoles via a regioselective C-H functionalization/C-O bond formation under an air atmosphere
Ueda, Satoshi,Nagasawa, Hideko
supporting information; experimental part, p. 4272 - 4277 (2009/09/08)
(Chemical Equation Presented) An efficient method for the synthesis of functionalized benzoxazoles is described that involves a copper(II)-catalyzed regioselective C-H functionalization/C-O bond formation protocol. The use of dichlorobenzene as a solvent at 160°C allows the use of air as the terminal oxidant in the catalytic synthesis of benzoxazoles in a process that has high functional group tolerance. The presence of a directing group at the meta position markedly improves the reaction efficacy and a variety of 7-substituted benzoxazoles are selectively produced under mild reaction conditions. The mechanism of the reaction is also discussed in this report.
Metasubstituted thiazolidinones, their manufacture and use as a drug
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Page/Page column 35, (2010/11/25)
This invention involves thiazolidinone of general formula (I) and its creation and use as inhibitors of polo like kinase (PLK) for the treatment of various diseases.
Thiazolidinones, their production and use as pharmaceutical agents
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, (2008/06/13)
Thiazolidinones of general formula I in which Q, A, B, X, R1 and R2 have the meanings that are indicated in the description, as well as those of general formula IA in which Q, A, B, X, R1 and R2a have the meanings that are indicated in the description, their production and use as inhibitors of the polo-like kinase (PLK) for treating various diseases as well as intermediate products for the production of thiazolidinones are described.
Meta-bifunctional benzenes and herbicidal compositions
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, (2008/06/13)
Meta-bifunctional of the general formula EQU1 wherein A is selected from the groups EQU2 These compounds possess herbicidal activity.
