4143-38-8

Basic information

• Product Name: O,O-diethyl S-p-tolyl phosphorothioate
• Synonyms: O,O-diethyl S-p-tolyl phosphorothioate
• CAS NO: 4143-38-8
• Molecular Weight: 260.294
• Mol File: 4143-38-8.mol
• Article Data: 39

Chemical Properties

• CAS DataBase Reference: O,O-diethyl S-p-tolyl phosphorothioate(CAS DataBase Reference)
• NIST Chemistry Reference: O,O-diethyl S-p-tolyl phosphorothioate(4143-38-8)
• EPA Substance Registry System: O,O-diethyl S-p-tolyl phosphorothioate(4143-38-8)

Safety Data

• Hazardous Substances Data: 4143-38-8(Hazardous Substances Data)

Upstream product

• 814-49-3 diethyl chlorophosphate 
• 106-45-6 para-thiocresol 
• 5852-63-1 sodium diethylthiophosphate 
• 762-04-9 phosphonic acid diethyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 536-57-2 p-toluene sulfinic acid 
• 122-52-1 triethyl phosphite 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 2943-42-2 di(4-methyl)phenylthiosulfonate 
• 933-00-6 p-methylbenzenesulfenyl chloride 
• 2768-31-2 benzyl diethyl phosphite 
• 106-49-0 p-toluidine 
• 657-84-1 sodium tosylate 
• 123726-16-9 bis(4-methylphenyl)iodonium trifluoromethanesulfonate 

Downstream Products

• 303174-10-9 diethyl N-(4-methylphenyl)methylphosphoramidate 
• 53640-96-3 diethyl N-benzylphosphoramidate 
• 98643-06-2 diethyl N-(4-methoxyphenyl)methylphosphoramidate 

Relevant articles and documents

Sulfonyl-Promoted Michaelis-Arbuzov-Type Reaction: An Approach to S/Se-P Bonds

By facilitating the chemical conversion of thiols to thiosulfonates, phosphoramidite/phosphite bearing sp3-hybridized carbon serves as an ideal coupling material to forge new connections at room temperature. In this work, a functional group-induced, additive-free, novel, S-P bond-forming approach is presented. This protocol exhibits good functional group tolerance with wide applications that include phosphorylation of cysteine derivatives, development of a one-pot approach to mixed unsymmetrical thiophosphonates, and extension of the concept to different Se-P bonds. Meticulously, our reaction also generated a S-P bond against cyclic 1,2-dithiane-1-dioxide in a byproduct-free manner. These Michaelis-Arbuzov-type reactions are easy to conduct, work efficiently in a reduced reaction time, and are applicable to gram-scale preparation as well.

Tf2O/DMSO-Promoted P-O and P-S Bond Formation: A Scalable Synthesis of Multifarious Organophosphinates and Thiophosphates

A Tf2O/DMSO-based system for the dehydrogenative coupling of a wide range of alcohols, phenols, thiols, and thiophenols with diverse phosphorus reagents has been developed. This metal- and strong-oxidant-free strategy provides a facile approach to a great variety of organophosphinates and thiophosphates. The simple reaction system, good functional-group tolerance, and broad substrate scope enable the application of this method to the modification of natural products and the direct synthesis of bioactive molecules and flame retardants.

An Alternative Metal-Free Aerobic Oxidative Cross-Dehydrogenative Coupling of Sulfonyl Hydrazides with Secondary Phosphine Oxides

An alternative metal-free, efficient and practical approach for the preparation of phosphinothioates is established via the aerobic oxidative cross-dehydrogenative coupling (CDC) of sulfonyl hydrazides with secondary phosphine oxides catalyzed by tetrabutylammonium iodide (TBAI) in the presence of atmospheric oxygen. The strategy provides an array of diverse phosphinothioates in good to excellent yields. Furthermore, two representative bioactive molecules are synthesized on up to gram scale by utilizing this method.