4144-55-2

Upstream product

• 54050-30-5 4-oxo-dodec-2t-enoic acid 
• 33018-77-8 5-octyl-2-oxo-2,3-dihydro-furan-3,4-dicarboxylic acid diethyl ester 
• 127014-85-1 2,2-dimethyl-5-(2-oxodecyl)-1,3-dioxane-4,6-dione 
• 59941-35-4 4-Oxododecansaeure-ethylester 
• 64807-34-7 4-hydroxy-2-dodecynoic acid 
• 39727-88-3 1-bromo-2-decanone 
• 55446-76-9 n-octyl-magnesium iodide 
• 156992-85-7 5-n-octyl-2,3-dihydrofuran 
• 112-80-1 cis-Octadecenoic acid 
• 137669-45-5 3-Aethoxycarbonyl-3-dodecensaeure 
• 6404-94-0 2-nonylidenesuccinic acid 
• 856362-66-8 1,1,1-trichloro-2-hydroxy-dodecan-4-one 
• 693-54-9 Decan-2-one 
• 872-05-9 1-Decene 

Downstream Products

• 33566-59-5 methyl 4-oxo-dodecanoate 
• 57084-18-1 gamma-dodecalactone 
• 69830-91-7 (R)-4-dodecanolide 
• 69830-92-8 5(S)-octyl-2(3H)-dihydrofuranone 

Relevant academic research and scientific papers

MODIFIED AMINE LIPIDS

The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.

Cerulenin analogues as inhibitors of efflux pumps in drug-resistant candida albicans

Overexpression of the ABC transporters Cdrl and Cdr2 or the major facilitator Mdrl causes multidrug resistance in the human fungal pathogen Candida albicans. The fatty acid synthesis inhibitor cerulenin and the structurally unrelated Golgi transport inhibitor brefeldin A are substrates for both types of efflux pumps in Candida albicans. In an effort to overcome efflux pump-mediated drug resistance in Candida albicans, cerulenin analogues were generated using a variety of synthesis pathways. The so obtained cerulenin derivatives were tested on multidrug-resistant Candida albicans isolates which constitutively overexpress either Mdr1 or Cdr1 and Cdr2. Some of these compounds were found to decrease Mdr1-mediated resistance to brefeldin A up to eight-fold compared to the control. 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages

The synthesis of the analogs of N-3-oxododecanoyl-l-homoserine lactone (1) and their structure-activity relationship for the apoptotic induction in macrophages, P388D1 cells, are described. It was revealed that the position of the oxo group in the acyl si

Method for preparing chiral diphosphines

The invention concerns a method for preparing a compound of formula (1) wherein: A represents naphthyl or phenyl optionally substituted; and Ar1, Ar2independently represent a saturated or aromatic carbocyclic group, optionally substituted.

Asymmetric hydrogenation method of a ketonic compound and derivative

The present invention relates to a process for the asymmetric hydrogenation of a ketonic compound and derivative. The invention relates to the use of optically active metal complexes as catalysts for the asymmetric hydrogenation of a ketonic compound and derivative. The process for the asymmetric hydrogenation of a ketonic compound and derivative is characterized in that the asymmetric hydrogenation of said compound is carried out in the presence of an effective amount of a metal complex comprising as ligand an optically active diphosphine corresponding to one of the following formulae: STR1

SYNTHESIS OF 4-OXODODECANOIC AND 4-OXODODECANEDIOIC ACIDS

A short synthesis is described for 4-oxododecanoic acid starting from 1-decene or 2-decanone and of 4-oxododecanedioic acid from the methyl ester of 9-oxodecanoic acid.

Synthesis of Racemates and (+)-Enantiomers of γ-Caprolactone, γ-Dodecanolactone and δ-Hexadecanolactone, Lactonic Sex Pheromones of the Dermestid Beetle, Rove Beetle and Oriental Hornet

A simple method based on regioselective two-step alkylation of easily-available diethyl 3-oxoglutarate (2) is described for the synthesis of racemates of the lactonic pheromones, 1a, 1b, and 1c.Their (+)-enantiomers were also synthesized by means of microbiological reduction of the intermediary keto acids.

Total Syntheses of (+/-)-Cerulenin, (+/-)-Tetrahydrocerulenin, and Related Compounds

The total synthesis of the microbial metabolite (+/-)-cerulenin (1) is described.Detailed evidence for the cyclization of cerulenin to a mixture of hydroxy lactams 2 is presented.The successful synthetic approach to cerulenin uses butenolide 3 as a key intermediate.Sodium hypochlorite in pyridine was found to epoxidize the butenolide system nicely; all other methods investigated failed.The syntheses of (+/-)-tetrahydrocerulenin 25 and a number of related compounds are also described.