59941-35-4Relevant articles and documents
Synthesis of functionalized dialkyl ketones from carboxylic acid derivatives and alkyl halides
Wotal, Alexander C.,Weix, Daniel J.
supporting information; experimental part, p. 1476 - 1479 (2012/05/21)
Unsymmetrical dialkyl ketones can be directly prepared by the nickel-catalyzed reductive coupling of carboxylic acid chlorides or (2-pyridyl)thioesters with alkyl iodides or benzylic chlorides. A wide variety of functional groups are tolerated by this process, including common nitrogen protecting groups and C-B bonds. Even hindered ketones flanked by tertiary and secondary centers can be formed. The mechanism is proposed to involve the reaction of a (L)Ni(alkyl)2 intermediate with the carboxylic acid derivative.
