13893-43-1

Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-AMINO-PENTANOIC ACID ETHYL ESTER is used as a chiral building block for the synthesis of various pharmaceutical products. Its application is due to its ability to contribute to the creation of enantiomerically pure drugs, which are essential for ensuring the desired therapeutic effects and minimizing potential side effects.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (R)-2-AMINO-PENTANOIC ACID ETHYL ESTER is used as a precursor in the preparation of enantiomerically pure drugs. Its application is based on its chiral nature, which allows for the development of more effective and targeted medications with fewer side effects.
Used in Organic Chemistry Research:
(R)-2-AMINO-PENTANOIC ACID ETHYL ESTER is also utilized in organic chemistry research, where it serves as a valuable compound for the development of new drugs and other biologically active compounds. Its application in this field is due to its unique chemical properties and potential for further modification and functionalization.
Used in Drug Development:
(R)-2-AMINO-PENTANOIC ACID ETHYL ESTER has potential applications in the development of new drugs, as it can be used as a starting material or a key intermediate in the synthesis of novel pharmaceutical compounds. Its application in drug development is driven by its biological activity and the possibility of creating enantiomerically pure drugs with improved therapeutic profiles.

Upstream product

• 64-17-5 ethanol 
• 760-78-1 2-aminopentanoic acid 
• 7463-34-5 2-hydroxyimino-valeric acid ethyl ester 
• 7647-01-0 hydrogenchloride 
• 860748-87-4 2-nitroso-valeric acid ethyl ester 
• 2531-82-0 ethyl 2-nitropentanoate 
• 64-19-7 acetic acid 
• 1048676-58-9 ethyl N-(diphenylmethylene)-2-aminopentanoate 
• 24317-96-2 2-propyl-3-oxo-3-phenylpropionic acid ethyl ester 

Downstream Products

• 42930-57-4 2-(2-Benzoylamino-2-methyl-propionylamino)-pentanoic acid ethyl ester 
• 149207-93-2 2-{[1-Phenyl-meth-(E)-ylidene]-amino}-pentanoic acid ethyl ester 
• 2013-12-9 D-norvaline 
• 6600-40-4 L-Norvaline 
• 4146-04-7 DL-2-amino-1-pentanol 
• 5632-87-1 N-benzoylnorvaline 

Relevant academic research and scientific papers

Efficient synthesis of α-substituted amino acid ester: Alkylation and hydrogenation removal of Schiff's base protecting group

A general and efficient synthetic route to α-amino acids by alkylation of the sodium salt of Schiff base ester 1 has been described previously. The α-substituted ethyl glycinates 4a-g are prepared in excellent yield by a two-step sequence involving regios

Palladium-Catalyzed Allylic Alkylation of Aldimine Esters with Vinyl-Cyclopropanes to Yield α,α-Disubstituted α-Amino Acid Derivatives

A synthetically useful approach for the synthesis of functionalized α, α-disubstituted α-amino acid derivatives via palladium-catalyzed 1,7 addition of readily available aldimine esters to vinylcyclopropanes is reported. This methodology was operated under mild conditions, affording α-allylic α-amino esters in good to excellent yields and excellent regio- and stereoselectivity. This transformation displays broad functional-group tolerance and enantioselective allylic alkylation has also been realized using a chiral phosphine ligand to provide the desired product. (Figure presented.).

Synthesis of some new 5-arylidene-2,4-thiazolidinedione esters

Compounds containing the 1,3-thiazolidine-2,4-dione scaffold are gaining increasing scientific interest as potential interventional agents for a variety of disease states. A four-step synthesis of ethyl-(2-(5-arylidine-2,4- dioxothiazolidin-3-yl)acetyl)glycinates, alaninates, butanoates, valinates and norvalinates is described. The synthesis began by converting 1,3-thiazolidine-2,4-dione into its potassium salt, which was treated with ethyl (2-chloroacetamido)glycinates, alaninates, butanoates, valinates and norvalinates, respectively, to obtain the penultimate products. These products were then subjected to a Knoevenagel condensation reaction with different aldehydes to obtain the desired products in low to excellent yields.