4146-16-1

Usage

Physical state

Colorless to white crystalline solid

Solubility

Soluble in water

Function

Reducing agent in organic chemistry and pharmaceutical synthesis

Applications

a. Production of drugs (e.g., penicillamine, tiopronin)
b. Chemical modification of proteins and peptides
c. Manufacturing of specialty chemicals
d. Building block in the synthesis of complex organic molecules

Upstream product

• 4146-19-4 2,5-dimethylthiazoline 
• 1437-90-7 5-methylthiazolidine-2-thione 

Downstream Products

• 67189-38-2 (+/-)-5-Methyl-2-phenyl-thiazolidin 
• 116112-98-2 2-Isopropyl-5-methyl 1,3-thiazolane 
• 67189-38-2 (+)-5-Methyl-2-phenyl-thiazolidin 
• 93332-72-0 1-<4-Nitro-benzamino>-2-<(4-nitro-benzoyl)-mercapto>-propan 

Relevant academic research and scientific papers

ANTHRACYCLINE DISULFIDE INTERMEDIATES, ANTIBODY-DRUG CONJUGATES AND METHODS

The invention provides antibody-drug conjugates comprising an antibody conjugated to an anthracycline drug moiety via a disulfide linker, anthracycline disulfide intermediates, and methods of using the antibody-drug conjugates.

Synthesis and Insecticidal Activity of Oxazaphospholidines, Oxathiaphospholanes, and Thiazaphospholidines

Fifty-five new five-membered cyclic organophosphorus compounds including oazaphospholidines, thiazaphospholidines, and oxathiaphospholanes were synthesized, which have substituents at 4- or/and 5-positions besides at the 2-position.The thiazaphospholidines showed the highest insecticidal activity followed by oxathiaphospholanes and oxazaphospholidines.The position preference of substituents in insecticidal activity was most obvious in the oxazaphospholidines.It was preferable for insecticidal activity to have the substituent near the more basic atom: the 4-position for thiazaphospholidine and oxazaphospholidine, the 5-position for oxathiaphospholane, with the exception of 4- or 5-phenyl oxazaphospholidine.