1437-90-7

Basic information

• Product Name: 5-methyl-1,3-thiazolidine-2-thione
• CAS NO: 1437-90-7
• Molecular Formula: C₄H₇NS₂
• Molecular Weight: 133.2351
• Mol File: 1437-90-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 194°C at 760 mmHg
• Flash Point: 71.1°C
• Density: 1.28g/cm³
• Vapor Pressure: 0.452mmHg at 25°C
• Refractive Index: 1.638
• CAS DataBase Reference: 5-methyl-1,3-thiazolidine-2-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-1,3-thiazolidine-2-thione(1437-90-7)
• EPA Substance Registry System: 5-methyl-1,3-thiazolidine-2-thione(1437-90-7)

Safety Data

• Hazardous Substances Data: 1437-90-7(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 926-25-0 2-amino-1-methlethyl hydrogen sulfate 
• 78-96-6 3-amino-2-propanol 
• 2403-33-0 2-bromopropylamine hydrobromide 

Downstream Products

• 4146-16-1 1-amino-2-propanethiol hydrochloride 
• 115273-31-9 2-(benzylthio)-5-methyl-4,5-dihydro-1,3-thiazole 

Relevant articles and documents

Synthesis and Fungicidal Activity of Simple Structural 1,3-Thiazolidine-2-Thione Derivatives

A series of simple structural 1,3-thiazolidine-2-thione derivatives with various substituents on the S-, N-, 4-, and 5-positions was synthesized with high yields from various vicinal amino alcohols via two steps and screened for their antifungal activity. Bioassay results reveal that some thiazolidine-2-thione derivatives show strong antifungal activities against P. capsici, G. zeae, S. sclerotiorum, A. alternata, B. cinerea, or R. solani. The SAR analysis indicates that N-acyl substituted and 4-alkyl substituents can enhance the antifungal activity. Notably, 4-isopropyl-N-propionylthiazoldine-2-thione shows excellent activity against B. cinerea and G. zeae with IC50 values at 3.7 g/mL and 6.5 g/mL, respectively, and 4-isobutyl-N-propionylthiazoldine-2-thione shows remarkable fungicidal activity against R. solani, S. sclerotiorum, and G. zeae with IC50 values at 1.0 g/mL, 12.1 g/mL, and 11.0 g/mL, respectively. GRAPHICAL ABSTRACT.

GENE DELIVERY MEDIATED BY LIPOSOME-DNA COMPLEX WITH CLEAVABLE PEG SURFACE MODIFICATION

A liposome composition and method for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a cationic lipid and (ii) a lipid joined to a hydrophilic polymer by a releasable linkage. The liposomes are associated with a nucleic acid for delivery to a cell.

Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2- imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.