4146-19-4

Basic information

• Product Name: 2,5-dimethyl-4,5-dihydro-1,3-thiazole
• Synonyms: 2,5-Dimethyl-4,5-dihydro-1,3-thiazole; thiazole, 4,5-dihydro-2,5-dimethyl-
• CAS NO: 4146-19-4
• Molecular Formula: C₅H₉NS
• Molecular Weight: 115.1967
• Mol File: 4146-19-4.mol

Chemical Properties

• Boiling Point: 147.1°C at 760 mmHg
• Flash Point: 42.8°C
• Density: 1.13g/cm³
• Vapor Pressure: 5.69mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: 2,5-dimethyl-4,5-dihydro-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dimethyl-4,5-dihydro-1,3-thiazole(4146-19-4)
• EPA Substance Registry System: 2,5-dimethyl-4,5-dihydro-1,3-thiazole(4146-19-4)

Safety Data

• Hazardous Substances Data: 4146-19-4(Hazardous Substances Data)

Upstream product

• 2403-33-0 2-bromopropylamine hydrobromide 
• 62-55-5 thioacetamide 
• 64-19-7 acetic acid 
• 78-96-6 3-amino-2-propanol 
• 75-36-5 acetyl chloride 
• 4293-57-6 N-(2-hydroxypropyl)-acetamide 

Downstream Products

• 40052-04-8 N-benzoyl-thioglycine S-{1-methyl-2-[1-(5-oxo-2-phenyl-oxazol-4-ylidene)-ethylamino]-ethyl} ester 
• 40217-46-7 N-benzoyl-glycine 2-[1-(5-oxo-2-phenyl-oxazol-4-ylidene)-ethylsulfanyl]-propylamide 
• 598-36-7 1-amino-2-propanethiol 
• 4146-16-1 1-amino-2-propanethiol hydrochloride 
• 816455-93-3 1-(3,5-dimethylthiazolidin-2-ylidene)-3,3-dimethylbutan-2-one 

Relevant articles and documents

Generation of cyclic ketene-N,X-acetals (X = O, S) from 2-alkyl-1,3-oxazolines and 2-alkyl-1,3-thiazolines. Reactions with acid chlorides, 1,3-diacid chlorides and N-(chlorocarbonyl) isocyanate

2-Alkyl-1,3-oxazolines, 2-alkyl-1,3-thiazolines, and the corresponding cyclic ketene-N,X-acetals (X = O, S) derived from them were reacted with monoacid chlorides, diacid chlorides, triacid chlorides. A series of these carbon-carbon bond-forming reactions and cyclizations to both substituted 2,3-dihydrooxazolo[3,2-a]pyridine-5,7-diones and 2,3-dihydrothiazolo[3,2-a] pyridine-5,7-diones proceeded under mild reaction conditions. Cyclic ketene-N,X-acetal intermediates play important roles in all these reactions. Related cyclizations with N-(chlorocarbonyl) isocyanate formed substituted 2,3-dihydrooxazolo[3,2-c]pyrimidine-5,7-diones and 2,3-dihydrothiazolo[3,2-c] pyrimidine-5,7-diones. Georg Thieme Verlag Stuttgart.

Reactions of 2-methylthiazolines and N-methyl cyclic ketene-N,S-acetals with acid chlorides

Carbon-carbon bond formation occurs under mild conditions when 2-methylthiazolines react with acid chlorides to form N-acyl-β-keto cyclic ketene-N,S-acetals. N-Methyl cyclic ketene-N,S-acetals, generated from 2-methyl-thiazolines, can react further with acid chlorides to form N-methyl-β-keto cyclic ketene-N,S-acetals.

Research on radioprotective agents: Δ-2 Thiazolines and homologous derivatives

Compounds derived from Δ-2 thiazoline, Δ-2 thiazolinium iodoalkylate and 4,5-dihydro-1,3 thiazine have been prepared and evaluated as potential antiradiation agents in mice. They generally have a low toxicity and significant radioprotective activity.