41480-08-4

Usage

Uses

Used in Chemical Production:
2-methylphenyl benzenesulfonate serves as an intermediate in the synthesis of a variety of organic chemicals and pharmaceuticals. Its unique structure and reactivity make it a valuable component in the creation of diverse chemical products.
Used in Organic Chemical Synthesis:
As a reagent, 2-methylphenyl benzenesulfonate is utilized in organic chemical synthesis processes. Its role is crucial in facilitating specific reactions that contribute to the formation of desired organic compounds.
Used in Pharmaceutical Industry:
Given its involvement in the production of pharmaceuticals, 2-methylphenyl benzenesulfonate plays a significant role in the development and manufacturing of various medications, potentially impacting the treatment and management of different health conditions.
Safety Note:
It is imperative to handle 2-methylphenyl benzenesulfonate with care due to its potential to cause irritation to the skin, eyes, and respiratory system if proper safety measures are not adhered to.

Upstream product

• 95-48-7 ortho-cresol 
• 98-09-9 benzenesulfonyl chloride 
• 873-55-2 sodium benzenesulfonate 

Downstream Products

• 107189-77-5 (2-formylphenyl) benzenesulfonate 
• 82745-71-9 2-phenylsulfonyloxybenzoic acid 
• 2091-60-3 2-bromomethylphenyl benzenesulfonate 
• 213257-69-3 N-(2-methylphenyl)benzophenone hydrazone 
• 290353-25-2 5-(4,5-dimethoxy-2-iodophenyl)-4-(2-hydroxyphenyl)-1-phenylpyrazole 
• 291537-05-8 2-[5-(4,5-dimethoxy-2-iodophenyl)-1-phenyl-1H-pyrazol-4-yl]phenyl benzenesulfonate 
• 478316-28-8 2-[2-(4,5-dimethoxy-2-iodophenyl)-2-oxo-ethyl]phenyl benzenesulfonate 
• 291536-97-5 2-[2-(N,N-dimethylamino)-1-(4,5-dimethoxy-2-iodobenzoyl)vinyl]phenyl benzenesulfonate 
• 95-48-7 ortho-cresol 
• 90-02-8 salicylaldehyde 
• 529-19-1 2-Methylbenzonitrile 
• 69-72-7 salicylic acid 

Relevant academic research and scientific papers

Practical Electro-Oxidative Sulfonylation of Phenols with Sodium Arenesulfinates Generating Arylsulfonate Esters

A practical and sustainable synthesis of arylsulfonate esters has been developed through electro-oxidation. This reaction employed the stable and readily available phenols and sodium arenesulfinates as the starting materials and took place under mild reaction conditions without additional oxidants. A wide range of arylsulfonate esters including those bearing functional groups were produced in good to excellent yields. This reaction could also be conducted at a gram scale without a decrease of reaction efficiency. Those results well demonstrated the potential synthetic value of this reaction in organic synthesis.

Deprotection of durable benzenesulfonyl protection for phenols — efficient synthesis of polyphenols

A robust protection method for phenol was demonstrated by the use of durable benzenesulfonyl group, which survives various harsh reaction conditions using Grignard reagent, organolithium reagent, metal alkoxide, phosgene, mineral, and Lewis acids. A facile deprotection condition utilizing pulverized KOH (5 equiv) and t-BuOH (10 equiv) in hot toluene makes this protocol as a practical method, which can be applied to the multistep synthesis of biologically and medicinally important polyphenol compounds.

Highly efficient Pd-catalyzed cyanation of aryl chlorides and arenesulfonates with potassium ferrocyanide in aqueous media

A highly improved Pd-catalyzed cyanation of aryl chlorides to corresponding benzonitriles was demonstrated in aqueous media. Moreover, Pd-catalyzed cyanation of aryl tosylates and benzenesulfonates with K4[Fe(CN) 6] was developed under the similar conditions, which extended application scope of the cyanation. Graphical Abstract: [Figure not available: see fulltext.]

Revisiting the Ullmann-ether reaction: A concise and amenable synthesis of novel dibenzoxepino[4,5-d]pyrazoles by intramolecular etheration of 4,5-(o,o′-halohydroxy)arylpyrazoles

A concise synthesis of a series of novel dibenzoxepino[4,5-d]pyrazoles was accomplished by implementation of an intramolecular Ullmann-ether reaction on o,o'-halohydroxy-4,5-diarylpyrazoles mediated by CuBr·DMS. An alternative useful approach based on the palladium-catalyzed biarylether linkage formation (Buchwald-Hartwig reaction) was also successfully applied, offering limitations with regard to the steric demand of the substituents. The synthesis of the key o,o′-halohydroxy-4,5-diarylpyrazole intermediates proceeds through the construction of the heterocyclic ring by a tandem amine-exchange/heterocyclization sequence of 3-N,N-(dimethylamino)-1,2-diarylpropenones with phenylhydrazine followed by basic hydrolysis for deprotection. The enamino ketone precursors were conveniently prepared from the corresponding O-sulfonyloxy and O-benzoyloxy ortho-substituted 1,2-diarylethanones, starting from inexpensive salicylaldehyde or phenylacetic derivatives. Preliminary binding affinity experiments against peripheral and central nervous system receptors have been done with negative results.