414867-64-4

Upstream product

• 220536-15-2 C₂₃H₂₂N₄O₆ 
• 220529-51-1 (methoxy-phenyl)-(4-nitro-imidazol-1-yl)-acetic acid ethyl ester 
• 77629-83-5 ethyl 2-bromo-2-(4-methoxyphenyl) acetate 
• 14062-18-1 ethyl p-methoxyphenylacetate 
• 220536-10-7 2-(4-Methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-propionic acid ethyl ester 

Downstream Products

• 220536-24-3 C₁₉H₂₄N₄O₄ 
• 811795-90-1 [1-(1-{1-[1-(4-methoxy-phenyl)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl]-1H-imidazol-4-ylcarbamoyl}-4-phenyl-butylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester 
• 220907-93-7 3-[2-(4-methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one 
• 811795-87-6 2-(4-methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-1-pyrrolidin-1-yl-propan-1-one 
• 414867-62-2 (R)-2-(4-Methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-propionic acid 

Relevant academic research and scientific papers

Method for treating emesis with ghrelin agonists

The present invention relates to a method comprising administering to a patient diagnosed as being in need of treatment for nausea, emesis, or symptoms associated therewith comprising administering to a patient in need thereof a compound of formula (I) wh

Synthesis and biological evaluation of an orally active ghrelin agonist that stimulates food consumption and adiposity in rats

LY444711 is an orally active ghrelin agonist that binds with good affinity and is a potent activator of the growth hormone secretagogue receptor 1a (GHS-R1a) receptor. In rat models of feeding behavior and pharmacology, LY444711 creates a positive energy

Growth hormone secretagogues

What is disclosed are growth hormone secretagogues, and their uses, of the formula wherein R1 is C6H5CH2OCH2—, C6H5(CH2)3— or indol-3-ylmethyl; Y is pyrrolidin-1-yl, 4-C1-C6alkylpiperidin-1-yl or NR2R2; R2 are each independently a C1to C6alkyl; R3 is 2-napthyl or phenyl para-substituted by W; W is H, F, CF3, C1-C6alkoxy or phenyl; and R4 is H or CH3, or a pharmaceutically acceptable salt or solvate thereof.