77629-83-5

Upstream product

• 5720-07-0 4-methoxyphenylboronic acid 
• 105-36-2 ethyl bromoacetate 
• 36141-66-9 ethyl 2-hydroxy-2-(4-methoxyphenyl)acetate 
• 14062-18-1 ethyl p-methoxyphenylacetate 
• 107445-17-0 ethyl 2-diazo-2-(4-methoxyphenyl) acetate 
• 104-01-8 4-Methoxyphenylacetic acid 
• 64-17-5 ethanol 
• 100-66-3 methoxybenzene 
• 40140-16-7 ethyl (p-methoxyphenyl)oxoacetate 

Downstream Products

• 131403-77-5 1-<2-(α-ethoxycarbonyl-p-methoxybenzyl)thiophenyl>pyrrole 
• 680617-59-8 ethyl α-(4-methoxy-phenyl)-α-[(4-(1H-pyrrol-1-yl)-3-pyridyl)thio]acetate 
• 287393-03-7 ethyl [4-(hydroxyphenyl)sulfanyl](4-methoxyphenyl)acetate 
• 152302-86-8 Ethyl α-(diethoxyphosphinyl)-α-(4-methoxyphenyl)acetate 
• 155908-91-1 2-chloro-6-(p-methoxyphenyl)pyrrolo<2,1-d><1,5>benzothiazepin-7(6H)-one 
• 155908-82-0 p-methoxy-α-<<4-chloro-2-(1H-pyrrol-1-yl)phenyl>thio>phenylacetic acid 
• 155908-96-6 2-methoxy-6-(p-methoxyphenyl)pyrrolo<2,1-d><1,5>benzothiazepin-7(6H)-one 
• 155909-15-2 7-acetoxy-2-chloro-6-(p-methoxyphenyl)pyrrolo<2,1-d><1,5>benzothiazepine 
• 155908-87-5 (4-Methoxy-phenyl)-(4-methoxy-2-pyrrol-1-yl-phenylsulfanyl)-acetic acid 
• 155908-90-0 6-(p-methoxyphenyl)-2-(trifluoromethyl)pyrrolo<2,1-d><1,5>benzothiazepin-7(6H)-one 
• 155908-81-9 (4-Methoxy-phenyl)-(2-pyrrol-1-yl-4-trifluoromethyl-phenylsulfanyl)-acetic acid 
• 145729-87-9 2-(4-methoxyphenyl)-1-trimethylsilylmethylpiperazine 
• 145729-89-1 4-acetyl-2-(4-methoxyphenyl)-1-trimethylsilylmethylpiperazine 
• 145729-85-7 3-(4-methoxyphenyl)-4-trimethylsilylmethylpiperazin-2-one 

Relevant academic research and scientific papers

Bromination of α-Diazo Phenylacetate Derivatives Using Cobalt(II) Bromide

A method for the bromination of α-diazo phenylacetate derivatives using cobalt(II) bromide is described. This bromination reaction features a short reaction time, broad substrate scope, operational simplicity, acid-free conditions, and gram-scalability. (Figure presented.).

Regioselective and Stereoselective Heck-Matsuda Arylations of Trisubstituted Allylic Alkenols and Their Silyl and Methyl Ether Derivatives to Access Two Contiguous Stereogenic Centers: Expanding the Redox-Relay Process and Application in the Total Synthesis of meso-Hexestrol

Novel palladium-catalyzed redox-relay Heck arylation reactions of trisubstituted allylic alkenols were developed employing silyl and methyl ethers. The reactions proceeded under mild conditions in moderate to high yields in an excellent anti diastereoselectivity to form α,β-disubstituted methyl ketones containing two contiguous stereocenters. The new redox-relay arylations using silyl and methyl ethers of the starting alkenols demonstrate that the presence of a free hydroxyl group is not a sine qua non condition for an effective redox-relay process as previously thought. Deuterium-labeled alkenols 2-d-10a, 2-d-10b, and 2-d-10c permitted tracking the palladium-hydride reinsertion steps in the conversion of the starting free alcohols, silyl, and methyl ethers into the corresponding methyl ketone 3-d-11a, with >98% deuterium retention. Moreover, the synthetic potential of the method was demonstrated with a straightforward synthesis of the meso-hexestrol in 4 steps, in 41% overall yield from alkenol 10a.

Mechanochromic Polymers That Turn Green Upon the Dissociation of Diarylbibenzothiophenonyl: The Missing Piece toward Rainbow Mechanochromism

Mechanochromic polymers, that is, polymers sensitive to mechanical impact, promise great potential for applications in damage sensors. In particular, radical-type mechanochromic polymers, which produce colored radical species in response to mechanical str

Pd-catalyzed divergent C(sp2)-H Activation/Cycloimidoylation of 2-Isocyano-2,3-diarylpropanoates

A Pd-catalyzed site-selective C(sp2)-H activation/cycloimidoylation of 2-isocyano-2,3-diarylpropanoates to construct diverse cyclic imine products has been developed. Six-membered 3,4-dihydroisoquinolines containing a C3 quaternary carbon cente

Construction of Pyrrolo[1,2-a]indoles via Cobalt(III)-Catalyzed Enaminylation of 1-(Pyrimidin-2-yl)-1H-indoles with Ketenimines and Subsequent Base-Promoted Cyclization

A cobalt(III)-catalyzed cross-coupling reaction of 1-(pyrimidin-2-yl)-1H-indoles with ketenimines is reported. The reaction provided 2-enaminylated indole derivatives in moderate to excellent yields with a broad substrate scope. The prepared 2-enaminylated indoles could be conveniently converted into pyrrolo[1,2-a]indoles, which are an important class of compounds in medicinal chemistry.

Synthesis of α,α-disubstituted α-amino esters: Nucleophilic addition to iminium salts generated from amino ketene silyl acetals

Alkoxycarbonyl iminium species are prepared easily by the oxidation of tetrasubstituted amino ketene silyl acetals, and subsequent nucleophilic addition of Grignard reagents to the iminium salts gives α,α- disubstituted α-amino ester derivatives in moderate to good yields, in which aryl and ethynyl substituents are readily introduced.

Generation of iminyl copper species from α-azido carbonyl compounds and their catalytic C-C bond cleavage under an oxygen atmosphere

Figure presented A copper-catalyzed reaction of α-azidocarbonyl compounds under an oxygen atmosphere is reported where nitriles are formed via C-C bond cleavage of a transient iminyl copper intermediate. The transformation is carried out by a sequence of denitrogenative formation of iminyl copper species from α-azidocarbonyl compounds and their C-C bond cleavage, where molecular oxygen (1 atm) is a prerequisite to achieve the catalytic process and one of the oxygen atoms of O2 was found to be incorporated into the β-carbon fragment as a carboxylic acid.

TRANSLOCATOR PROTEIN LIGANDS

The present invention relates to compounds and methods for imaging translocator protein (18 kDa) (TSPO) expression in a subject. This invention also relates to compounds and methods for the treatment of neurodegenerative disorders, inflammation or anxiety in a subject.

Iminyl radicals from α-azido o-iodoanilides via 1,5-H transfer reactions of aryl radicals: New transformation of α-azido acids to decarboxylated nitriles

(Chemical Equation Presented) The radical reaction of tributyltin hydride with o-iodo-N-methylanilides derived from α-azido acids provides an excellent access to α-(aminocarbonyl)iminyl radicals through 1,5-hydrogen transfer reaction of initially formed aryl radicals followed by β-elimination of dinitrogen from ensuing α-azido-α- (aminocarbonyl)alkyl radicals. The outcoming iminyls display a peculiar tendency to form corresponding nitriles by β-elimination of aminocarbonyl radicals.

Reliable and versatile synthesis of 2-aryl-substituted cinnamic acid esters

2-Aryl-substituted phosphono acetates can be readily synthesized by a four-step sequence from the respective arenes. Succeeding Horner-Wadsworth- Emmons olefinations provide stereoselectively the 2-aryl cinnamic acid esters even when sensitive moieties are involved. Georg Thieme Verlag Stuttgart.