4149-00-2

Upstream product

• 118-48-9 isatoic anhydride 
• 95-54-5 1,2-diamino-benzene 
• 463-71-8 thiophosgene 
• 54255-86-6 N-<2-aminobenzoil>-o-fenilendiamina 
• 109287-33-4 trans-3-(2-nitrophenyl)oxirane-2-carboxamide 
• 51679-86-8 2-(2-amino-2-oxoacetamido)benzoic acid 
• 552-89-6 2-nitro-benzaldehyde 
• 88-74-4 2-nitro-aniline 

Downstream Products

• 116121-27-8 10-Benzyl-10H-4b,10,11-triaza-benzo[b]fluoren-5-one 
• 32700-97-3 6-Ethyl-benzimidazo<1,2-b>chinazolin-12(6H)-on 
• 32701-00-1 5-benzylbenzimidazo[2,1-b]quinazolin-12(5H)-one 
• 32701-08-9 6-(2-oxo-2-phenyl-ethyl)-6H-benzo[4,5]imidazo[2,1-b]quinazolin-12-one 

Relevant academic research and scientific papers

New and efficient synthesis of 3-arylquinazolin-4(1H)-ones and biologically important N-fused tetracycles based on N-(2-carboxyphenyl)oxalamide

A novel clean, one-pot syntheses of 3-arylquinazolin-4(3H)-ones and quinoxalino[2,1-b]quinazoline-6,12(5H)-diones via PPA-mediated coupling of N-(2-carboxyphenyl)oxalamides with arylamines and 1,2-benzenediamines have been developed. Under mild reaction conditions with use of Na2S2O4 the benzimidazo[2,1-b]quinazolin-12-ones were achieved in good yield from 3-(2-nitrophenyl)quinazolin-4-ones.

Microwave-mediated heterocyclization to benzimidazo[2,1-b]quinazolin-12(5H) -ones

An effective route to benzimidazo[2,1-b]quinazolin-12(5H)-ones from commercially available o-aryl isothiocyanate esters and o-phenylenediamines is reported. This method accommodates a variety of substituents on either starting material and proceeds under microwave irradiation in the presence of barium hydroxide, conditions that do not hydrolyze methyl ester substituents. The pharmacologically pertinent benzimidazoquinazolinone heterocycle is delivered in excellent yield and purity via both solution- and solid-phase protocols, the latter involving traceless release from the resin.

Reaction of isatoic anhydride with bifunctional reagents: Synthesis of some new quinazolone fused heterocycles, 2-substituted anilinoheterocyclic derivatives and other related compounds

A new synthesis of quinazolone fused heterocycles (2, 5, 8), anilinoheterocycles (4, 7, 10, 12, 14) and substituted 2-aminoquinoline (15, 16) based on the reaction of isatoic anhydride (1) with different active bifunctional compounds in presence of glacial acetic acid and freshly fused sodium acetate is described. Structures of the newly prepared compounds are established by chemical and spectral data.

Synthesis of Benzimidazoquinazolines - Mechanism of Thiophosgene Heterocyclisation

A number of benzimidazoquinazolines (5-9) have been synthesized starting from 2-(2'-aminophenyl)benzimidazole (3).Reaction of 2-aminoanthranilide (2) with thiophosgene has been carried out and the mechanism of thiophosgene heterocyclisation has been discussed.The compounds have been tested for their anthelmintic and antinmicrobial activities but none of them shows any noteworthy activity.