51679-86-8Relevant articles and documents
New and efficient synthesis of 3-arylquinazolin-4(1H)-ones and biologically important N-fused tetracycles based on N-(2-carboxyphenyl)oxalamide
Mamedov, Vakhid A.,Mamedova, Vera L.,Syakaev, Victor V.,Gubaidullin, Aidar T.,Voronina, Julia K.,Kushatov, Temur A.,Korshin, Dmitry E.,Samigullina, Aida I.,Tanysheva, Ekaterina G.,Kh. Rizvanov, Il'dar,Latypov, Shamil K.
, (2021/09/28)
A novel clean, one-pot syntheses of 3-arylquinazolin-4(3H)-ones and quinoxalino[2,1-b]quinazoline-6,12(5H)-diones via PPA-mediated coupling of N-(2-carboxyphenyl)oxalamides with arylamines and 1,2-benzenediamines have been developed. Under mild reaction conditions with use of Na2S2O4 the benzimidazo[2,1-b]quinazolin-12-ones were achieved in good yield from 3-(2-nitrophenyl)quinazolin-4-ones.
Synthesis, crystal structure, cytotoxicities and DNA-binding properties of a tetracopper(II) complex with N-benzoato-N0-[2-(2-hydroxyethylamino)ethyl- amino]oxamide ligand
Chen, Wen-Cai,Wang, Ling-Dong,Li, Yan-Tuan,Wu, Zhi-Yong,Yan, Cui-Wei
, p. 569 - 577 (2012/11/13)
A new dissymmetrical N,N'-bis(substituted)- oxamide ligand, N-benzoato-N'-[2-(2- hydroxyethylamino)- ethyl]oxamide (H3bhyox), and its tetranuclear copper(II) complex, [Cu4(bhyox)2(dabt) 2](ClO4)2 (1) have been synthesized and characterized (dabt = 2,2'-diamino- 4,4'-bithiazole). The crystal structures of H3bhyox and complex 1 have been determined by X-ray single-crystal diffraction. Complex 1 has a cyclic tetranuclear cation with an embedded inversion center, in which the Cu-Cu separations through the oxamido and carboxyl bridges are 5.2246(6) and 5.3141(6) A , respectively. Both Cu(II) centers at the inner and outer sites of the cis-bhyox3- ligand have square pyramidal geometries. There is a 3D hydrogen-bonding network in the crystal. The cytotoxicities and DNA-binding properties of H3bhyox and complex 1 were studied. Both compounds can interact with HS- DNA by intercalation, and the DNA-binding affinities are consistent with their in vitro cytotoxicities. Springer Science+Business Media B.V. 2012.
