41563-76-2Relevant academic research and scientific papers
A general N-alkylation procedure for ethyl pyroglutamate
Simandan, Tiberiu,Smith, Michael B.
, p. 1827 - 1838 (1996)
Despite several reported procedures for coupling alkyl halides and 5-oxoproline esters (pyroglutamate derivatives), no general method has been described. The reaction of pyrroglutamate with sodium hydride, in anhydrous THF in the presence of the halide, p
