A general N-alkylation procedure for ethyl pyroglutamate

Article abstract of DOI:10.1080/00397919608002625

Despite several reported procedures for coupling alkyl halides and 5-oxoproline esters (pyroglutamate derivatives), no general method has been described. The reaction of pyrroglutamate with sodium hydride, in anhydrous THF in the presence of the halide, p

Full text of DOI:10.1080/00397919608002625

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A General N-Alkylation
Procedure for Ethyl
Pyroglutamate
Tiberiu Simandan a & Michael B. Smith a
a Room 151, 215 Glenbrook Road, Department
of Chemistry, University of Connecticut, Storrs,
Connecticut, 06269-3060
Version of record first published: 21 Aug 2006.
To cite this article: Tiberiu Simandan & Michael B. Smith (1996): A General N-
Alkylation Procedure for Ethyl Pyroglutamate, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 26:9,
1827-1838
To link to this article: http://dx.doi.org/10.1080/00397919608002625
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