4162-55-4

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Trifluoromethyl-pentanedioic acid is used as a key intermediate in the synthesis of pharmaceuticals for various therapeutic applications. Its unique chemical structure, including the trifluoromethyl group, contributes to the development of new drugs with improved pharmacological properties.
Used in Agrochemical Production:
TFPD is also utilized in the production of agrochemicals, such as pesticides and herbicides, to enhance their effectiveness in controlling pests and weeds. The incorporation of the trifluoromethyl group in these compounds can lead to increased stability and bioactivity.
Used in Organic Chemistry as a Building Block:
3-Trifluoromethyl-pentanedioic acid serves as a versatile building block in organic chemistry, allowing for the creation of a wide range of fluorinated compounds with diverse applications. Its reactivity and stability make it a valuable component in the synthesis of complex organic molecules for various industries.

InChI:InChI=1S/C6H7F3O4/c7-6(8,9)3(1-4(10)11)2-5(12)13/h3H,1-2H2,(H,10,11)(H,12,13)

Upstream product

• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 107-91-5 cyanoacetic acid amide 
• 25597-16-4 ethyl 4,4,4-trifluorocrotonate 
• 105-53-3 diethyl malonate 
• 138852-02-5 diethyl 3-(trifluoromethyl)pentanedioate 
• 853644-35-6 α,α'-dicyano-β-trifluoromethylglutamide 
• 1841-65-2 3-Trifluormethyl-glutarsaeure-dianilid 

Downstream Products

• 39890-98-7 2,6-dichloro-4-(trifluoromethyl)pyridine 

Relevant academic research and scientific papers

Stereoselective aldol reaction of glutarimides using pseudo C2 symmetry

(Figure presented) The boron aldol reaction of β-substituted glutaric imldes bearing an oxazolidinone-based auxiliary proceeds with excellent diastereoselectivity; switching the tertiary amine employed between /-Pr 2EtN or Et3N affor

Design, synthesis, and antipicornavirus activity of 1-[5-(4-arylphenoxy) alkyl]-3-pyridin-4-ylimidazolidin-2-one derivatives

A series of pyridylimidazolidinone derivatives was synthesized and tested in vitro against enterovirus 71 (EV71). On the basis of compound 33 (DBPR103), introduction of a methyl group at the 2- or 3-position of the linker between the imidazolidinone and the biphenyl resulted in markedly improved antiviral activity toward EV71 with IC50 values of 5.0 nM (24b) and 9.3 nM (14a), respectively. Increasing the branched chain to propyl resulted in a progressive decrease in activity, while inserting different heteroatoms entirely rendered the compound only weakly active. The introduction of a bulky group (cyclohexyl, phenyl, or benzyl) led to loss of activity against EV71. The 4-chlorophenyl moiety in 14a was replaced with bioisosteric groups such as oxadiazole (28a-d) or tetrazole (32a,b), dramatically improving anti-EV71 activity and selectivity indices. Compounds 14a, 24b, 28b, 28d, and 32a exhibited a strong activity against lethal EV71, and no apparent cellular toxicity was observed. Three of the more potent imidazolidinone compounds, 14a, 28b, and 32b, were subjected to a large group of picornaviruses to determine their spectrum of antiviral activity.

Synthesis of novel analogues of marine indole alkaloids: Mono(indolyl)-4-trifluoromethylpyridines and bis(indolyl)-4-trifluoromethylpyridines as potential anticancer agents

Mono(indolyl)-4-trifluoromethylpyridines and bis(indolyl)-4-trifluoromethylpyridines were synthesized using Suzuki cross-coupling reaction between 2-chloro-4-trifluoromethylpyridine 9, 2,6-dichloro-4-trifluoromethylpyridine 6 or 2,6-dichloro-3-cyano-4-tri

Convenient approaches to 4-trifluoromethylpyridine

A number of approaches to the synthesis of 2-chloro-and 2,6-dichloro-4-trifluoromethylpyridine are described. The first method for 2-chloro-and 2,6-dichloro-4-trifluoromethylpyridine is based on commercially available ethyl trifluoroacetate. An alternative access to 2,6-dichloro-4-trifluoromethyl pyridine uses trifluoroacetaldehyde as starting material. 2-Chloro-4-trifluoromethylpyridine is prepared from ethyl(trifluoroacetylvinyl)ether in two steps.

Herbicidal glutaramic acids and derivatives

This invention relates to glutaramic acids and derivatives exhibiting herbicidal activity having the structure STR1 wherein A is a carboxylic acid or a derivative thereof, D is CH or N, and R, R1, R2, T, X, Y, and Z are as defined within, compositions containing these compounds and methods of controlling weeds with these compounds.