41635-75-0

Upstream product

• 805189-00-8 4-Dimethylamino-1,1-bis-<4-methoxy-phenyl>-buten-(1) 
• 98451-48-0 3,3-Bis-(4-methoxy-phenyl)-cyclohex-4-ene-1,1,2,2-tetracarbonitrile 
• 28228-81-1 bis(p-methoxyphenyl)methylenecyclopropane 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 21821-17-0 4-Dimethylamino-1,1-bis-<4-methoxy-phenyl>-butanol-(1) 
• 1730-25-2 allylmagnesium bromide 
• 696-62-8 para-iodoanisole 
• 18925-10-5 allylzinc bromide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 7152-03-6 p-methoxyphenyl cyclopropyl ketone 
• 106-95-6 allyl bromide 
• 556-56-9 allyl iodid 
• 41004-19-7 1-iodo-3-methyl-but-2-ene 

Downstream Products

• 100036-29-1 3-[2,2-Bis-(4-methoxy-phenyl)-vinyl]-cyclobutane-1,1,2,2-tetracarbonitrile 
• 98451-48-0 3,3-Bis-(4-methoxy-phenyl)-cyclohex-4-ene-1,1,2,2-tetracarbonitrile 
• 100036-13-3 2-[(E)-5,5-Bis-(4-methoxy-phenyl)-1,1-bis-trifluoromethyl-penta-2,4-dienyl]-malononitrile 

Relevant academic research and scientific papers

An Example of Ketone Olefination via Praseodymium-Mediated Barbier Reaction in the Presence of Diethyl Phosphite

The first example of carbon double-bond formation via praseodymium-mediated Barbier type reaction of ketones and allyl halides in the presence of diethyl phosphite is reported. The reaction is highly α-regioselective and conveniently carried out under mild conditions in a one-pot fashion. From a synthetic point of view, a series of conjugated alkenes were obtained in moderate to good yields in this one-pot reaction with practical reaction conditions.

Neodymium-Promoted Highly Selective Carbon-Carbon Double Bond Formation of Ketones with Allyl Halides in the Presence of Diethyl Phosphite

The carbon-carbon double bond formation via neodymium-mediated Barbier-type reaction of ketones and allyl halides in the presence of diethyl phosphite is reported for the first time. The reaction is highly α-regioselective and was conveniently carried out under mild conditions in a one-pot fashion. From a synthetic point of view, a series of conjugated alkenes were obtained in moderate to good yields in this one-pot reaction with feasible reaction conditions.

Pd(0)-catalyzed cross-coupling of allyl halides with α-diazocarbonyl compounds or N-mesylhydrazones: Synthesis of 1,3-diene compounds

With palladium catalysis, allyl bromides or chlorides react with α-diazocarbonyl compounds or N-mesylhydrazones to afford 1,3-diene derivatives. The reaction represents a novel and efficient method for the synthesis of 1,3-butadiene derivatives. Mechanist

Palladium-catalyzed cross-coupling of cyclopropylmethyl N-tosylhydrazones with aromatic bromides: An easy access to multisubstituted 1,3-butadienes

Direct synthesis of 1,1-disubstitued 1,3-butadienes has been efficiently realized from the cross-coupling of cyclopropylmethyl N-tosylhydrazones with aromatic bromides by means of PdCl2(MeCN)2 as catalyst. 1,1,4-Trisubstitued 1,3-but

A novel ketone olefination via organozinc reagents in the presence of diphenyl phosphite

Carbonyl compounds react with organozinc reagents in the presence of diphenyl phosphite to give the corresponding olefins. A variety of 1,3-dienes and unsaturated esters were obtained in moderate to excellent yields under mild conditions. The Royal Society of Chemistry 2012.

Cyclopropylmethyl palladium species from carbene migratory insertion: New routes to 1,3-butadienes

Cyclopropylmethyl palladium species can be accessed by Pd-catalyzed reaction of either cyclopropyl N-tosylhydrazone with halide or N-tosylhydrazone with cyclopropyl halide. In both approaches migratory insertion of Pd carbene is the key process. These transformations constitute new approaches toward 1,3-butadiene derivatives.

A novel and efficient method for the olefination of carbonyl compounds with Grignard reagents in the presence of diethyl phosphite

The widely available carbonyl compounds react with Grignard reagents in the presence of diethyl phosphite to give the corresponding olefins in good to excellent yields: A range of conjugated dienes, terminal olefins, multisubstituted-alkenes and conjugated enynes could be readily obtained by the method in mild conditions.

Palladium-catalyzed isomerization of methylenecyclopropanes in acetic acid

PD(PPh3)4-catalyzed isomerization of MCPs 1 in acetic acid proceeds smoothly at 80 °C in toluene to give the corresponding I-substituted or 1,1-disubstituted dienes 2 in good to excellent yields under mild conditions. The plausible mechanism has been disclosed on the basis of a deuterium-labeling experiment.

Reaktion von trans-1-Arylbutadienen und 1,1-Diarylbutadienen mit Tetracyanethylen (TCNE) und 2,2-Bis(trifluormethyl)ethylen-1,1-dicarbonitril (BTF): Kinetische Studie

Kinetic data (substituent effects, solvent effects, activation parameter) are reported for the reactions of trans-1-arylbutadienes 1 and 1,1-diarylbutadienes 3 with TCNE 4 and BTF 5. (2+2)- and (4+2)-cycloadducts 7 respectively 9 can rearrange or undergo cycloreversions with quite different reaction rates depending on the substituent in the aryl-ring.