41658-69-9Relevant articles and documents
Merrifield resin-supported chain transfer agents, precursors for RAFT polymerization
Takolpuckdee, Pittaya,Mars, Craig A.,Perrier, Sebastien
, p. 3449 - 3452 (2005)
(Chemical Equation Presented) The modification of Merrifield resins to form chain transfer agent (CTA) precursors for reversible addition fragmentation chain transfer (RAFT) polymerization is investigated. A series of CTA precursor resins were prepared an
C(sp3)-H Fluorination with a Copper(II)/(III) Redox Couple
Bower, Jamey K.,Cypcar, Andrew D.,Henriquez, Brenda,Stieber, S. Chantal E.,Zhang, Shiyu
supporting information, p. 8514 - 8521 (2020/05/28)
Despite the growing interest in the synthesis of fluorinated organic compounds, few reactions are able to incorporate fluoride ions directly into alkyl C-H bonds. Here, we report the C(sp3)-H fluorination reactivity of a formally copper(III) fluoride complex. The C-H fluorination intermediate, LCuF, along with its chloride and bromide analogues, LCuCl and LCuBr, were prepared directly from halide sources with a chemical oxidant and fully characterized with single-crystal X-ray diffraction, X-ray absorption spectroscopy, UV-vis spectroscopy, and 1H nuclear magnetic resonance spectroscopy. Quantum chemical calculations reveal significant halide radical character for all complexes, suggesting their ability to initiate and terminate a C(sp3)-H halogenation sequence by sequential hydrogen atom abstraction (HAA) and radical capture. The capability of HAA by the formally copper(III) halide complexes was explored with 9,10-dihydroanthracene, revealing that LCuF exhibits rates 2 orders of magnitude higher than LCuCl and LCuBr. In contrast, all three complexes efficiently capture carbon radicals to afford C(sp3)-halogen bonds. Mechanistic investigation of radical capture with a triphenylmethyl radical revealed that LCuF proceeds through a concerted mechanism, while LCuCl and LCuBr follow a stepwise electron transfer-halide transfer pathway. The capability of LCuF to perform both hydrogen atom abstraction and radical capture was leveraged to enable fluorination of allylic and benzylic C-H bonds and α-C-H bonds of ethers at room temperature.
Radical-triggered three-component coupling reaction of alkenylboronates, α-halocarbonyl compounds, and organolithium reagents: The inverse ylid mechanism
Tappin, Nicholas D. C.,Gn-Gi-lux, Manuel,Renaud, Philippe
supporting information, p. 11498 - 11502 (2018/10/21)
An operationally simple protocol to affect a radical addition to alkenylboronates that spontaneously undergo a [1,2]-metalate shift is described. Overall, the reaction is a three-component coupling of an organolithium, alkenylboronic ester, and halide which takes place with broad scope and good to excellent yields. Experimental mechanistic investigations support the formation of a boron inverse ylid intermediate.
