4167-06-0Relevant articles and documents
A facile chemoenzymatic approach to natural cytotoxic ellipsoidone A and natural ellipsoidone B
Gogoi, Sanjib,Argade, Narshinha P.
, p. 2715 - 2720 (2006)
Starting from citraconic anhydride (3) a facile four-step synthesis of deoxyellipsoidone 8 has been reported with 37% overall yield. An elegant six-step access to naturally occurring cytotoxic ellipsoidone A (1) and ellipsoidone B (2) has been reported with good overall yields, via the conversion of itaconic anhydride (9) to the acetoxymethylmaleic anhydride (11), regioselective sodium borohydride reduction of anhydride 11 to acetoxymethylbutyrolactone 12, Knoevenagel condensation of lactone 12 with 5-methylfurfural, selenium dioxide induced oxidation of the formed butenolide 13 and an Amano PS catalyzed deacylation of the formed diacetoxybutenolide 14 as a pathway.
A synthesis of (±)-sparteine
Buttler, Thomas,Fleming, Ian,Gonsior, Sabine,Kim, Bo-Hye,Sung, A.-Young,Woo, Hee-Gweon
, p. 1557 - 1567 (2007/10/03)
In a synthesis of racemic sparteine, Diels Alder reaction between dimethyl bromomesaconate 14 and dicyclopentenyl 4, followed by cyclopropane formation, set up the stereochemistry at C-1 and C-5 as S and R, respectively, in a meso intermediate 8. The ster
