4167-06-0

Basic information

• Product Name: 2-bromo-2-(bromomethyl)butanedioic acid
• CAS NO: 4167-06-0
• Molecular Formula: C₅H₆Br₂O₄
• Molecular Weight: 289.9067
• Mol File: 4167-06-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 292.3°C at 760 mmHg
• Flash Point: 130.6°C
• Density: 2.287g/cm³
• Vapor Pressure: 0.000458mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 2-bromo-2-(bromomethyl)butanedioic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-2-(bromomethyl)butanedioic acid(4167-06-0)
• EPA Substance Registry System: 2-bromo-2-(bromomethyl)butanedioic acid(4167-06-0)

Safety Data

• Hazardous Substances Data: 4167-06-0(Hazardous Substances Data)

Upstream product

• 2170-03-8 itaconic acid anhydride 
• 97-65-4 2-methylenesuccinic acid 

Downstream Products

• 10035-10-6 hydrogen bromide 
• 97-65-4 2-methylenesuccinic acid 
• 7553-56-2 iodine 
• 81189-55-1 acetic acid 5-oxo-2,5-dihydrofuran-3-ylmethyl ester 
• 26735-82-0 2-bromomethylmaleic anhydride 
• 2957-09-7 2,3-dihydroxy-1,2-propanedicarboxylic acid 

Relevant articles and documents

A facile chemoenzymatic approach to natural cytotoxic ellipsoidone A and natural ellipsoidone B

Starting from citraconic anhydride (3) a facile four-step synthesis of deoxyellipsoidone 8 has been reported with 37% overall yield. An elegant six-step access to naturally occurring cytotoxic ellipsoidone A (1) and ellipsoidone B (2) has been reported with good overall yields, via the conversion of itaconic anhydride (9) to the acetoxymethylmaleic anhydride (11), regioselective sodium borohydride reduction of anhydride 11 to acetoxymethylbutyrolactone 12, Knoevenagel condensation of lactone 12 with 5-methylfurfural, selenium dioxide induced oxidation of the formed butenolide 13 and an Amano PS catalyzed deacylation of the formed diacetoxybutenolide 14 as a pathway.

Bromomesaconic and bromocitraconic acids. Potential active site labeling reagents for dicarboxylic acid metabolizing enzymes.

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