416864-75-0

Upstream product

• 5113-87-1 3-methyl-6-(prop-1-en-2-yl)cyclohexene 

Downstream Products

• 5113-94-0 (E)-2-methyl-2-(4-methylcyclohexyl)ethanol 
• 129145-23-9 (3R,6R)-3-Methyl-6-[1-methyl-2-((E)-2-methyl-buta-1,3-dienyloxy)-ethyl]-cyclohexene 
• 416864-77-2 2-((1R,4R)-4-Methyl-cyclohex-2-enyl)-propionic acid 
• 503272-14-8 (R)-2-{(1S,2S,3S,4R)-2-Hydroxy-4-methyl-3-[2-(2-methyl-[1,3]dithiolan-2-yl)-ethyl]-cyclohexyl}-propionic acid methyl ester 
• 503272-16-0 (R)-2-{(1S,3S,4R)-2-[1-Methoxy-meth-(E)-ylidene]-4-methyl-3-[2-(2-methyl-[1,3]dithiolan-2-yl)-ethyl]-cyclohexyl}-propionic acid methyl ester 
• 503272-15-9 (R)-2-{(1S,3S,4R)-4-Methyl-3-[2-(2-methyl-[1,3]dithiolan-2-yl)-ethyl]-2-oxo-cyclohexyl}-propionic acid methyl ester 
• 87322-20-1 (R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester 
• 63968-64-9 C₁₂H₁₃O₂(CH₃)3(O)(OO) 

Relevant academic research and scientific papers

Stereoselective total synthesis of (+)-artemisinin

The total synthesis of the novel antimalarial drug, a sesquiterpene endoperoxide, (+)-artemisinin is described. The approach is flexible and stereoselective. The use of an intermolecular radical reaction on an intermediate iodolactone and a Wittig reaction on a ketone were employed for the synthesis.

Stereoselective synthesis of artemisinin

A stereoselective synthesis of artemisinin 11 based on intramolecular Diels-Alder reaction of the triene 4 derived from (+)isolimonene 2 is described.