41733-86-2

Upstream product

• 67045-68-5 3-methyl-6-(3(R)-formylbutyl)salicylic acid benzyl ester 
• 31478-26-9 4(R)-<5(S)-ethyl-3(S)-methyl-5-(5(R)-ethyl-5-hydroxy-6(S)-methyl-2(R)-tetrahydropyranyl)-2(S)-tetrahydrofuryl>hexan-3-one 
• 100-39-0 benzyl bromide 
• 25999-20-6 lasalocid sodium 
• 75371-81-2 3-methyl-6-(3(R)-methyl-4,5-O-isopropylidenepentyl)salicylic acid methyl ester 
• 73657-51-9 benzyl 2(S)-<5(S)-ethyl-3(S)-methyl-5-(5(R)-ethyl-5-hydroxy-6(S)-methyl-2(R)-tetrahydropyranyl)-2(S)-tetrahydrofuryl>butyl ether 
• 73657-52-0 benzyl 2(S)-<5(S)-ethyl-3(S)-methyl-5-(3(R)-1,5-dioxo-4(S)-methylspiro<2.5>-6(R)-octyl)-2(S)-tetrahydrofuryl>butyl ether 
• 75371-80-1 2-(dibenzylamino)-3-methyl-6-(3(R)-methyl-4-pentenyl)benzoic acid methyl ester 
• 84985-06-8 benzyl 2(S)-<5(S)-carbomethoxy-3(S)-methyl-5-(5,6-dihydro)-5(S)-(methoxymethylenoxy)-6(S)-methyl-2(R)-pyranyl-2(S)-tetrahydrofuryl>butyl ether 
• 84911-36-4 2(S)-<5(S)-ethyl-3(S)-methyl-5-(5(R)-ethyl-5-(trimethylsiloxy)-6(S)-methyl-2(R)-tetrahydropyranyl)-2(S)-tetrahydrofuryl>butan-1-ol 
• 75371-87-8 2-amino-3-methyl-6-(3(R)-methyl-4,5-O-isopropylidenepentyl)benzoic acid methyl ester 
• 84911-38-6 (2S,6R)-6-[(2S,4S,5S)-5-((S)-1-Benzyloxymethyl-propyl)-2-ethyl-4-methyl-tetrahydro-furan-2-yl]-3-eth-(Z)-ylidene-2-methyl-tetrahydro-pyran 
• 84911-35-3 methyl 2(R)-<5(S)-ethyl-3(S)-methyl-5-(5(R)-ethyl-5-(trimethylsiloxy)-6(S)-methyl-2(R)-tetrahydropyranyl)-2(S)-tetrahydrofuryl>butanoate 
• 75371-89-0 2-(β-methoxyethoxymethyl)-3-methyl-6-(3(R)-methyl-4,5-O-isopropylidenepentyl)salicylic acid methyl ester 

Downstream Products

• 107449-44-5 6-{(E)-(3R,7R)-7-[(2S,3S,5S)-5-Ethyl-5-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyl-tetrahydro-pyran-2-yl)-3-methyl-tetrahydro-furan-2-yl]-3,5-dimethyl-6-oxo-non-4-enyl}-2-hydroxy-3-methyl-benzoic acid benzyl ester 
• 107449-45-6 6-{(E)-(3R,6S,7S)-7-[(2S,3S,5S)-5-Ethyl-5-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyl-tetrahydro-pyran-2-yl)-3-methyl-tetrahydro-furan-2-yl]-6-hydroxy-3,5-dimethyl-non-4-enyl}-2-hydroxy-3-methyl-benzoic acid benzyl ester 
• 107494-41-7 6-{(E)-(3R,6R,7S)-7-[(2S,3S,5S)-5-Ethyl-5-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyl-tetrahydro-pyran-2-yl)-3-methyl-tetrahydro-furan-2-yl]-6-hydroxy-3,5-dimethyl-non-4-enyl}-2-hydroxy-3-methyl-benzoic acid benzyl ester 
• 25999-31-9 lasalocid (X 537 A) 
• 107449-47-8 6-[(R)-3-((2R,3S)-3-{(R)-2-[(2S,3S,5S)-5-Ethyl-5-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyl-tetrahydro-pyran-2-yl)-3-methyl-tetrahydro-furan-2-yl]-butyryl}-3-methyl-oxiranyl)-butyl]-2-hydroxy-3-methyl-benzoic acid benzyl ester 
• 107449-47-8 6-[(R)-3-((2S,3R)-3-{(R)-2-[(2S,3S,5S)-5-Ethyl-5-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyl-tetrahydro-pyran-2-yl)-3-methyl-tetrahydro-furan-2-yl]-butyryl}-3-methyl-oxiranyl)-butyl]-2-hydroxy-3-methyl-benzoic acid benzyl ester 
• 107537-18-8 Lithium; 6-{(3R,4R,5R,7R)-7-[(2S,3S,5S)-5-ethyl-5-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyl-tetrahydro-pyran-2-yl)-3-methyl-tetrahydro-furan-2-yl]-4-hydroxy-3,5-dimethyl-6-oxo-nonyl}-2-hydroxy-3-methyl-benzoate 
• 107494-44-0 lithium lasalocid 
• 107449-46-7 6-[(R)-3-((2R,3R)-3-{(1S,2S)-2-[(2S,3S,5S)-5-Ethyl-5-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyl-tetrahydro-pyran-2-yl)-3-methyl-tetrahydro-furan-2-yl]-1-hydroxy-butyl}-3-methyl-oxiranyl)-butyl]-2-hydroxy-3-methyl-benzoic acid benzyl ester 
• 107449-46-7 6-[(R)-3-((2S,3S)-3-{(1S,2S)-2-[(2S,3S,5S)-5-Ethyl-5-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyl-tetrahydro-pyran-2-yl)-3-methyl-tetrahydro-furan-2-yl]-1-hydroxy-butyl}-3-methyl-oxiranyl)-butyl]-2-hydroxy-3-methyl-benzoic acid benzyl ester 

Relevant academic research and scientific papers

Stereoselective synthesis of polyether antibiotics, lasalocid A and isolasalocid A, via a chelation-controlled formation of tetrahydrofuran rings under thermodynamic conditions

The B-rings (2,5-trans-tetrahydrofurans) of lasalocid A (6) and isolasalocid A (7) were stereoselectively constructed from the corresponding p-methoxyphenylallyl alcohols (13a, 13b) by treatment with ZnBr2 to give C13-C24 fragments (14a, 14b) via a new chelation-controlled cyclization under thermodynamic conditions. After their conversion into lasalocid ketone (19) and BOM-isolasalocid ketone (20), coupling with the C1-C11 aldehyde (22) completed the synthesis of 6 and 7, respectively.