4176-74-3

Usage

Uses

Used in Pharmaceutical Industry:
4-(1,2-Diphenylethyl)morpholine is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its unique properties make it a valuable component in the development of new drugs and therapeutic agents.
Used in Chemical Industry:
4-(1,2-Diphenylethyl)morpholine is used as a reagent in organic synthesis. Its versatility allows it to be employed in a wide range of chemical reactions, contributing to the production of various chemical products.
Used in Medicinal Chemistry:
4-(1,2-Diphenylethyl)morpholine is used in medicinal chemistry for its potential to interact with biological systems. This interaction makes it a promising candidate for the development of new pharmaceuticals and therapeutic agents.

Upstream product

• 110-91-8 morpholine 
• 100-52-7 benzaldehyde 
• 6921-34-2 benzylmagnesium chloride 
• 501-65-5 diphenyl acetylene 
• 4176-69-6 (E)-N-(1,2-diphenylethenyl)morpholine 
• 20259-38-5 cis-Stilbenyl-diisobutyl-aluminium 
• 18239-50-4 1-morpholino-1,2-diphenylethene 
• 1468-28-6 4-benzoylmorpholine 

Relevant academic research and scientific papers

Achieving Aliphatic Amine Addition to Arylalkynes via the Lewis Acid Assisted Triazole-Gold (TA-Au) Catalyst System

Transition metal catalyzed intermolecular hydroamination of the arylalkynes with aliphatic amine is generally problematic due to the good coordination between amine and metal cation. With the combination of 1,2,3-triazole coordinated gold(I) catalyst (TA-Au) and Zn(OTf)2 cocatalyst, this challenging transformation was achieved with good to excellent yields and regioselectivity. Compared to previously reported methods, this approach offered an alternative catalyst system to achieve this fundamental chemical transformation with high efficiency and practical conditions.

Tertiary amine synthesis: Via reductive coupling of amides with Grignard reagents

A new iridium catalyzed reductive coupling reaction of Grignard reagents and tertiary amides affording functionalised tertiary amine products via an efficient and technically-simple one-pot, two-stage experimental protocol, is reported. The reaction-which can be carried out on gram-scale using as little as 1 mol% Vaska's complex [IrCl(CO)(PPh3)2] and TMDS as the terminal reductant for the initial reductive activation step-tolerates a broad range of tertiary amides from (hetero)aromatic to aliphatic (branched, unbranched and formyl) and a wide variety of alkyl (linear, branched), vinyl, alkynyl and (hetero)aryl Grignard reagents. The new methodology has been applied directly to bioactive molecule synthesis and the high chemoselectivity of the reductive coupling of amide has been exploited in late stage functionalization of drug molecules. This reductive functionalisation of tertiary amides provides a new and practical solution to tertiary amine synthesis.

Cu-Catalyzed electrophilic amination of internal alkynes via hydroalumination

A straightforward and efficient method for the synthesis of 1,2-diaryl-substituted enamines through the Cu-catalyzed electrophilic amination reaction of O-benzoyl hydroxylamines with vinylaluminum reagents generated in situ from the Ni-catalyzed hydroalumination of readily accessible internal aryl acetylenes is described. The amination is catalyzed by 1 mol% CuCl without any additive at ambient temperature to afford new versatile enamines in good yield (61-91%) with high selectivity (>98% E-enamine).

Stereo- and regioselective gold-catalyzed hydroamination of internal alkynes with dialkylamines

We report the use of a P,N-ligand to support a gold complex as a state-of-the-art precatalyst for the stereoselective hydroamination of internal aryl alkynes with dialkylamines to afford E-enamine products. Substrates featuring a diverse range of functional groups on both the amine (ether, sulfide, N-Boc amine, fluoro, nitrile, nitro, alcohol, N-heterocycles, amide, ester, and carboxylic acid) and alkyne (ether, N-heterocycles, N-phthalimide amines, and silyl ethers) are accommodated with synthetically useful regioselectivity.