41768-83-6Relevant academic research and scientific papers
COMPOUNDS AND COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISEASES
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Page/Page column 47, (2014/09/03)
The present application relates to a composition comprising a selective androgen modulating compound of formula (I) and selective estrogen receptor β agonist of formula (II). The present application also relates to the use of a selective androgen modulating compound of formula (I) in combination with a selective estrogen receptor β agonist of formula (II) in the treatment or prevention of neurodegenerative diseases or disorders,such as Alzheimer's disease, Huntigton's disease, Parkinson's disease, depression, anxiety, multiple sclerosis, symptoms associated with or caused by multiple sclerosis, and acute or chronic pain.
SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF
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Page/Page column 24, (2010/04/23)
The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): Wherein p, n, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.
COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS
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Page/Page column 58, (2010/11/30)
Disclosed herein are methods of treating neuropathic pain, reducing inflammation, reducing IL-4 levels, and reducing IFN-γ levels, using various di-aromatic compounds for use as estrogen receptors β agonists.
COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS
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Page/Page column 47, (2010/02/14)
Disclosed herein are novel di-phenyl compounds and methods for using various di-phenyl compounds for treatment and prevention of diseases and disorders related to estrogen receptors.
REACTION OF PHENOL WITH 1-PHENYL-1-CYCLOHEXENE IN THE PRESENCE OF ALUMINUM PHENOLATE
Kozlikovskii, Ya. B.,Koshchii, V. A.
, p. 844 - 846 (2007/10/02)
The reaction of phenol with 1-phenyl-1-cyclohexene in the presence of aluminum phenolate leads to 1-phenyl-1-(p-hydroxyphenyl)-, 1-phenyl-2-(p-hydroxyphenyl)-, 1-phenyl-2-(o-hydroxyphenyl)-, and 1-phenyl-3-(o-hydroxyphenyl)cyclohexanes, in which the ortho-alkylation products predominate.The products from ionic hydrogenation and dehydrogenation of the initial olefin (phenylcyclohexane and biphenyl) and a small amount of the products from the cleavage of the phenyl(hydroxyphenyl)cyclohexanes are also formed.
