417722-83-9

Upstream product

• 417721-38-1 6-carbamoyl-4-(4-amino-3-fluorophenoxy)-7-methoxyquinoline 
• 1885-14-9 phenyl chloroformate 
• 417721-36-9 4‐chloro‐7‐methoxyquinoline‐6‐carboxamide 
• 205448-66-4 methyl 4-chloro-7-methoxyquinoline-6-carboxylate 

Downstream Products

• 417718-45-7 N-(2-Fluoro-4-[(6-carbamoyl-7-methoxy-4-quinolyl)oxy]phenyl)-N'-cyclopentylurea 
• 417718-41-3 N-(2-fluoro-4-((6-carbamoyl-7-methoxy-4-quinolyl)oxy)phenyl)-N'-cyclopropyl urea 
• 417718-44-6 N-(2-Fluoro-4-[(6-carbamoyl-7-methoxy-4-quinolyl)oxy]phenyl)-N'-cyclobutylurea 
• 417716-82-6 4-(4-((3-Chloropropylamino)carbonyl)amino-3-fluorophenoxy)-7-methoxy-6-quinolinecarboxamide 
• 417719-59-6 4-(3-fluoro-4-(ethylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide 
• 417718-46-8 N-(2-Fluoro-4-[(6-carbamoyl-7-methoxy-4-quinolyl)oxy]phenyl)-N'-(2-propyl)urea 
• 417716-83-7 4-(3-Fluoro-4-((3-fluoropropylamino)carbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide 
• 417716-81-5 4-(3-fluoro-4-((2-fluoroethylamino)carbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide 

Relevant academic research and scientific papers

Multi-target tyrosine kinase inhibitor as well as preparation method and application thereof

The invention provides a compound as shown in a formula I or pharmaceutically acceptable salt thereof, which can inhibit various tyrosine kinases, has an inhibiting effect on VEGFR1, VEGFR2, VEGFR3, FGFR1, FGFR 2, FGFR 3, FGFR 4, PDGFR alpha, KIT, RET and the like, is used as a multi-target tyrosine kinase inhibitor, and has a potential application prospect in prevention and/or treatment of tumors related to tyrosine kinase overexpression.

Nitrogen-containing aromatic derivatives

Compounds represented by the following general formula: [wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a group represented by the following general formula: (wherein Eg is a single bond or —N(Rg2)—, Rg1 and Rg2 each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl group, etc. and Zg represents a C1-8 alkyl group, a C3-8 alicyclic hydrocarbon group, a C6-14 aryl group, etc.)], salts thereof or hydrates of the foregoing.