41780-25-0

Upstream product

• 636-99-7 4-nitrophenylhydrazine hydrochloride 
• 100-16-3 4-nitrophenylhydrazone 
• 40580-73-2 2-(4-nitrophenyl)hydrazin-1-carboxylic acid ethyl ester 

Downstream Products

• 80330-93-4 N'-(4-Nitro-phenyl)-N'-(2-oxo-cyclohexyl)-hydrazinecarboxylic acid ethyl ester 
• 1224434-08-5 2-(4-nitrophenyl)-N-(prop-2-ynyl)diazenecarboxamide 

Relevant academic research and scientific papers

Method for oxidizing and synthesizing azo compounds by taking hydrazine compounds as raw materials

The invention provides a method for synthesizing azo compounds, and the method takes hydrazine compounds as raw materials and trichloroisocyanuric acid as an oxidant to synthesize the azo compounds ina one-pot high-yield and high-efficiency manner in an organic solvent in an air atmosphere at room temperature. According to the method, the trichloroisocyanuric acid, which is low in price, green, nontoxic and highly efficient in oxidation, is used as the oxidant, and the trichloroisocyanuric acid is low in price, green and environment-friendly, stable in performance and high in use safety; thereaction solvent does not need special treatment, no byproduct is generated, the post reaction treatment is simple, the environmental pollution is small, the method is green and environment-friendly,and the method is suitable for industrial production.

Aerobic Oxidation of Alkyl 2-Phenylhydrazinecarboxylates Catalyzed by CuCl and DMAP

Recently, various fruitful organic reactions such as a catalytic Mitsunobu reaction were reported by virtue of alkyl 2-phenylazocarboxylates, however, the synthesis of alkyl 2-phenylazocarboxylates largely depended on the stoichiometric use of toxic oxidants. In this manuscript, an environment-friendly aerobic oxidative transformation of alkyl 2-phenylhydrazinecarboxylates to alkyl 2-phenylazocarboxylates is disclosed. The use of CuCl and DMAP system efficiently catalyzed the aerobic oxidation of alkyl 2-phenylhydrazinecarboxylates under mild conditions. The reaction rate of the present Cu-catalysis was much faster than that of the previously reported Fe-catalysis, and a variety of azo products were synthesized within 3 h. The present protocol was effective on larger scale. It was observed that the produced azo compound could undergo various reactions without isolation through one-pot sequential protocols.

Oxidation Potential Tunable Organic Molecules and Their Catalytic Application to Aerobic Dehydrogenation of Tetrahydroquinolines

In this work, oxidation potential tunable organic molecules, alkyl 2-phenyl hydrazocarboxylates, were disclosed. The exquisite tuning of their oxidation potentials facilitated a catalytic dehydrogenation of 1,2,3,4-tetrahydroquinolines in the presence of Mn(Pc) and O2.

Azocarbonyl-functionalized silanes

The invention provides azocarbonyl-functionalized silanes of the general formula I (R1)3-a(R2)aSi-RI-NH-C(O)-N=N-R4. They are prepared by a procedure in which in a first step hydrazine of t

Catalytic Aerobic Oxidation of Arylhydrazides with Iron Phthalocyanine

A convenient method for the synthesis of 2-arylazocarboxylates from 2-arylhydrazinecarboxylates by aerobic oxidation with iron phthalocyanine is described. The reaction is applicable to oxidative activation of 1-acyl-2-phenylhydrazines. Some preliminary experiments suggest Michaelis-Menten kinetics and participation of radical species in the reaction mechanism.

N-(Propargyl)diazenecarboxamides for 'click' conjugation and their 1,3-dipolar cycloadditions with azidoalkylamines in the presence of Cu(II)

Propargyl functionalized diazenes 1 were prepared by two different approaches and were examined as alkyne click components in copper-catalyzed azide-alkyne cycloadditions (CuAAC) with 2-(azidomethyl)pyridine 5a and four α-azido-ω-aminoalkanes C2-C5 (5b-e)

CAN-mediated oxidation of electron-deficient aryl and heteroaryl hydrazines and hydrazides

Aryl and heteroaryl hydrazines and hydrazides were successfully oxidised using CAN, deriving dehydrazinated products. The reaction pathway strongly depends on the nature of the substrate, resulting in the formation of hydrocarbons or alkoxy derivatives. When deuterated solvents such as methanol-d4 or acetonitrile-d3 were used, a regiospecific incorporation of deuterium was achieved. Georg Thieme Verlag Stuttgart.

1,3,4-OXADIAZINE DERIVATIVES FROM CYCLOHEXANONE ENAMINES AND ASYMMETRIC DIIMIDES; POSSIBILITY OF RING-CHAIN TAUTOMERISM IN SUCH HETEROCYCLIC SYSTEM

1,3,4-oxadiazine derivatives, in equilibrium with their corresponding trisubstituted enamine isomers, are obtained in a regiospecific way from cyclohexanone enamines and ethoxycarbonyl aroyl diimides.Such an equilibrium is not present in analogous oxadiazine systems, derived from aryl aroyl diimides.