41780-52-3

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 936231-00-4 1-benzyl-4-(benzyldimethylsilanyl)-1,2,3,6-tetrahydro-pyridine 
• 40240-12-8 1-benzyl-1,2,3,6-tetrahydropyridine 
• 1036203-25-4 1-benzyl-4-deuterio-1,2,3,6-tetrahydropyridine 
• 1591668-87-9 1'-benzyl-2',3'-dihydro-1'H,10H-spiro[acridine-9,4'-pyridine] 
• 1591669-01-0 1'-benzyl-2',3'-dihydro-1'H,10H-spiro[anthracene-9,4'-pyridine] 
• 1198408-35-3 6-amino-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-carboxylic acid tert-butyl ester 
• 928034-30-4 8-benzyl-1,8-diazaspiro[4.5]decane 
• 1591668-83-5 1'-benzyl-2',3'-dihydro-1'H-spiro[dibenzo[c,g]fluorene-7,4'-pyridine] 
• 1591668-71-1 1'-benzyl-2',3'-dihydro-1'H-spiro[fluorene-9,4'-pyridine] 
• 1393683-11-8 1-benzyl-4-(2-(4-(trifluoromethyl)phenyl)ethylidene)piperidine 
• 1393683-10-7 1-benzyl-4-(2-(4-methoxyphenyl)ethylidene)piperidine 
• 1393683-09-4 1-benzyl-4-(2-phenylethylidene)piperidine 
• 186347-72-8 4-phenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 936231-05-9 1-(tert-butoxycarbonyl)-4-(benzyldimethylsilanyl)-3,6-dihydro-2H-pyridine 

Relevant academic research and scientific papers

INHIBITORS OF THE N-TERMINAL DOMAIN OF THE ANDROGEN RECEPTOR

The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

Preparation method and intermediate of pyridinopyrimidine derivative

The invention relates to a preparation method and an intermediate of a pyridinopyrimidine derivative. Specifically, the invention provides a compound as shown in a formula I which is described in thespecification and a method for preparing the pyridinopyr

Process method suitable for amplification preparation of 4-(6-aminopyridin-3-yl) substituted piperidine

The invention discloses a process method suitable for amplification preparation of 4-(6-aminopyridin-3-yl) substituted piperidine, and belongs to the synthesis field of a medicine intermediate. N-substituted piperidone, aryl sulfohydrazide and 2-amino-5-bromopyridine are subjected to a coupling reaction under a palladium catalyst, and then are subjected to a hydrogenation to obtain 4-(6-aminopyridin-3-yl) substituted piperidine. According to the process, the raw materials in pyridine do not need to be protected; the condensation and the coupling are carried out in the same reaction kettle, sothat the operation cost is reduced, the steps of performing protection at first and then performing protection removal as in documents can be avoided, and production cost of the existing biological, medicine and chemical intermediates is greatly reduced; and the process is subjected to amplification verification in kilogram-scale, and the verification proves that the yield and the product purity are basically equal to those of gram-scale, so that the method can be used as a process for industrial scale production.

Palladium-Catalyzed Cross-Coupling of gem-Bis(boronates) with Aryl Halides: An Alternative to Access Quaternary α-Aryl Aldehydes

The compounds with a quaternary α-aryl aldehyde skeleton are important units in organic chemistry. Previously, the aryl group and carbonyl group are introduced in a stepwise manner. Herein, a novel route is developed to construct the quaternary α-aryl aldehydes with gem-bis(boronates) as precursors, in which the two groups are installed simultaneously. The gem-bis(boronates) are readily available from ketones; as a result, this methodology provides a more general strategy to produce the quaternary α-aryl aldehydes with broad scopes and synthetic convenience.

Difunctionalization of ketones: Via gem -bis(boronates) to synthesize quaternary carbon with high selectivity

All-carbon quaternary centres are significant and prevalent structural frameworks but their preparation routes are rare and challenging, especially methods with common substrates. Herein, we report a convenient process to construct all-carbon quaternary c

Olefination of carbonyl compounds through reductive coupling of alkenylboronic acids and tosylhydrazones

The partners decide: The C-C bond-forming reductive cross-coupling of alkenylboronic acids and tosylhydrazones takes place under mild reaction conditions without the need of a metal catalyst, thus giving rise to olefination-type products (see scheme). The position of the double bond in the product is determined by the structure of the coupling partners. Copyright

SYNTHESIS OF UNSATURATED PIPERIDINES FROM PIPERIDONES WITH A SILYL REAGENT

Syntheses of unsaturated piperidines from piperidones through a silyl pipehdine reagent via the Shapiro reaction and palladium-catalyzed cross- coupling reactions with organo halides.

Synthesis of 4-arylpiperidines from 1-benzyl-4-piperidone: Application of the shapiro reaction and alkenylsilane cross-coupling

Equation Presented 1-Benzyl-3,4-unsaturated-4-piperidinyl benzyldimethylsilane has been prepared and observed to readily undergo palladium-catalyzed cross-coupling reactions with a variety of aryl iodides and aryl bromides to generate 3,4-unsaturated 4-arylpiperidines, often at ambient temperature.