41789-48-4Relevant academic research and scientific papers
AZEPINE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS
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Page/Page column 6-7, (2009/04/25)
Compounds of formula (I), pharmaceutical compositions comprising them, and methods for their use are described.
1,2-Didehydroazepines from the Photolysis of Substituted Aryl Azides: Analysis of Their Chemical and Physical Properties by Time-Resolved Spectroscopic Methods
Li, Yu-Zhuo,Kirby, John P.,George, Michael W.,Poliakoff, Martyn,Schuster, Gary B.
, p. 8092 - 8098 (2007/10/02)
A series of substituted 1,2-didehydroazepines was prepared by photolysis of their precursor aryl azides.The chemical and physical properties of the didehydroazepines were probed by means of conventional chemical trapping experiments and by time-resolved spectroscopy with IR and UV detection.The didehydroazepines are formed from the azides with efficiencies that depend systematically on the nature of the substituent.In some cases, didehydroazepines are not formed at all.The didehydroazepines react relatively rapidly with starting aryl azide and with added amines.The rate of their reaction is largely controlled by the electronic properties of the substituent on the didehydroazepine.These results permit prediction of the reactivity of didehydroazepines from their structure.
The reactivity of the anion of 2-(diethylamino)-5-phenyl-3H-azepine. Synthesis of 3-substituted 2-(diethylamino)-5-phenyl-3H-azepines
Streef, J. W.,Plas, H. C. van der,Veldhuizen, A. van,Goubits, K.
, p. 225 - 232 (2007/10/02)
Deprotonation of 2-(diethylamino)-5-phenyl-3H-azepine (1) with different base systems yields an anionic species, which, on treatment with appropiate electrophiles, gives the 3-substituted derivatives of 1.
