4180-30-7

Usage

Uses

Used in Pharmaceutical Industry:
Piperazine, 1-methyl-4-[(4-methyl-1-piperazinyl)carbonyl]is used as an antipsychotic agent for the treatment of psychiatric disorders such as schizophrenia. It functions by blocking dopamine receptors in the brain, which helps in managing the symptoms of these disorders.
Used in Gastroenterology:
In the field of gastroenterology, Piperazine, 1-methyl-4-[(4-methyl-1-piperazinyl)carbonyl]may find applications in the treatment of certain gastrointestinal disorders. Its ability to influence neurotransmitter activity could potentially aid in the management of gastrointestinal motility and secretion issues.
Used as an Antihistamine:
Piperazine, 1-methyl-4-[(4-methyl-1-piperazinyl)carbonyl]also has potential applications as an antihistamine, where it could be utilized to counteract allergic reactions by blocking the effects of histamine, a neurotransmitter involved in immune responses.
While the provided materials do not explicitly list all the uses, the above applications are inferred based on the compound's properties and typical uses of similar compounds in the pharmaceutical and medical fields. Further research and clinical trials would be necessary to confirm these potential uses and establish safety and efficacy profiles.

Upstream product

• 109-01-3 1-methyl-piperazine 
• 75-44-5 phosgene 
• 201230-82-2 carbon monoxide 
• 56-23-5 tetrachloromethane 
• 39539-66-7 4-methyl-piperazine-1-carbonyl chloride 

Relevant academic research and scientific papers

Preparation method of substituted urea compound

The invention provides a preparation method of a substituted urea compound. The preparation method comprises the following steps: taking a nitrogen-containing heterocyclic compound and tetrahalomethane as raw materials, carrying out illumination catalytic reaction in the presence of a catalyst and a solvent to prepare the substituted urea compound and a halogen simple substance; the preparation method is wide in raw material source, phosgene, triphosgene and the like which are high in toxicity are prevented from being adopted as raw materials, the influence of the preparation process on the environment is reduced, and the atom utilization rate of the reaction is increased; the reaction conditions are mild, the operation is simple and convenient, the environmental pollution is reduced, and the reaction cost is reduced; the product yield is high, the halogen simple substance is co-produced, the additional value is high, a large amount of waste is prevented from being generated, and the method has high atom economy and environment friendliness and is beneficial to application and popularization.

Amine-Responsive Disassembly of AuI–CuI Double Salts for Oxidative Carbonylation

A sensitive amine-responsive disassembly of self-assembled AuI-CuI double salts was observed and its utilization for the synergistic catalysis was enlightened. Investigation of the disassembly of [Au(NHC)2][CuI2] revealed the contribution of Cu-assisted ligand exchange of N-heterocyclic carbene (NHC) by amine in [Au(NHC)2]+ and the capacity of [CuI2]? on the oxidative step. By integrating the implicative information coded in the responsive behavior and inherent catalytic functions of d10 metal complexes, a catalyst for the oxidative carbonylation of amines was developed. The advantages of this method were clearly reflected on mild reaction conditions and the significantly expanded scope (51 examples); both primary and steric secondary amines can be employed as substrates. The cooperative reactivity from Au and Cu centers, as an indispensable prerequisite for the excellent catalytic performance, was validated in the synthesis of (un)symmetric ureas and carbamates.

Organic ligand and solvent free oxidative carbonylation of amine over Pd/TiO2 with unprecedented activity

A highly active Pd/TiO2 catalyst system was prepared and applied in the oxidative carbonylation of amines to ureas with ultra-low Pd content under organic ligand and solvent free conditions. The catalytic turnover frequencies (TOFs, moles of amines converted per mole of Pd per h) were 126000 and 250000 h-1 for the production of diphenylurea and dibenzylurea, respectively. An expanded substrate scope including the electron-rich and electron-deficient anilines, primary aliphatic amines, secondary amines was also established. This work offers a straightforward, step economic, and green methodology for the efficient synthesis of valuable ureas.

Synthesis of 11C-Labelled Symmetrical Ureas via the Rapid Incorporation of [11C]CO2 into Aliphatic and Aromatic Amines

An efficient method to radiolabel symmetrical [11C]ureas using 1,8-diazabicycloundec-7-ene (DBU) and cyclotron-produced [11C]CO2 has been developed. [11C]urea derivatives were obtained when aliphatic and aromatic amines were used with excellent radiochemical yields (RCYs) of over 70%. The mechanism of the reaction is proposed on the basis of control experiments. This simple and robust methodology provides a powerful tool to prepare 11C-labelled ureas previously inaccessible by existing methods and enable their utilisation for in vivo molecular imaging applications.

NOVEL PIPERIDINE DERIVATIVES AS HISTAMINE H3 RECEPTOR LIGANDS FOR TREATMENT OF DEPRESSION

Compounds of formula (I) wherein Ar1 and Q are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the treatme