41803-67-2

Basic information

• Product Name: Pyrido[2,3-d]pyrimidine, 4-chloro-2-phenyl-
• CAS NO: 41803-67-2
• Molecular Formula: C13H8ClN3
• Molecular Weight: 241.68
• Mol File: 41803-67-2.mol

Chemical Properties

• CAS DataBase Reference: Pyrido[2,3-d]pyrimidine, 4-chloro-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[2,3-d]pyrimidine, 4-chloro-2-phenyl-(41803-67-2)
• EPA Substance Registry System: Pyrido[2,3-d]pyrimidine, 4-chloro-2-phenyl-(41803-67-2)

Safety Data

• Hazardous Substances Data: 41803-67-2(Hazardous Substances Data)

Upstream product

• 16081-87-1 2-phenylpyrido<2,3-d>pyrimidin-4(3H)-one 
• 14667-47-1 methyl 2-aminonicotinate 
• 144267-78-7 methyl 2-(N-benzoylamino)-nicotinate 
• 112084-93-2 2-(benzoylamino)-3-cyanopyridine 
• 98-88-4 benzoyl chloride 
• 24517-64-4 2-amino-3-pyridinecarbonitrile 

Downstream Products

• 41803-68-3 4-Amino-2-phenylpyrido<2,3-d>pyrimidin 
• 353278-21-4 2-phenyl-N-(3-(trifluoromethyl)phenyl)pyrido[2,3-d]pyrimidin-4-amine 

Relevant articles and documents

New Inhibitors of Breast Cancer Resistance Protein (ABCG2) Containing a 2,4-Disubstituted Pyridopyrimidine Scaffold

Multidrug resistance (MDR) occurring during cancer chemotherapy is a major obstacle for effectiveness and response to therapy and is often caused by ATP-binding cassette (ABC) efflux transporters. Belonging to the family of ABC transporters, breast cancer

Convenient and practical one-pot synthesis of 4-chloropyrimidines via a novel chloroimidate annulation

Reaction of aromatic or heteroaromatic 2-acyl(amino)nitriles with phosphorus pentachloride triggers a novel chloroimidate cyclization, leading directly to the corresponding annullated 4-chloropyrimidines in good to excellent yields. The reaction lends itself to the telescoped one-pot construction of 4-functionalized pyrimidines from the corresponding (hetero)aromatic 2-aminonitriles. For a pyrazolopyrimidine development intermediate, this reaction was scaled up to multikilogram scale with excellent results. A total of 10 examples with different substrates are provided. This one-pot reaction provides an attractive and sustainable alternative to the commonly used multistep methodology for this transformation.