41816-68-6

Usage

Uses

Used in Fragrance Industry:
1(2H)-Naphthalenone, 3,4-dihydro-2-(1-methylethyl)is used as a key ingredient in the fragrance industry for its pleasant floral scent reminiscent of violet and raspberry. It is utilized to impart a floral, fruity, and powdery note to perfumes and colognes.
Used in Flavoring Industry:
In the flavoring industry, 1(2H)-Naphthalenone, 3,4-dihydro-2-(1-methylethyl)is used as an additive in the production of food and beverages, enhancing their taste and aroma.
Used in Cosmetics and Personal Care Products:
1(2H)-Naphthalenone, 3,4-dihydro-2-(1-methylethyl)is also employed in the cosmetics and personal care products industry, where it contributes to the pleasant scent and overall sensory experience of these products.

Upstream product

• 75-30-9 2-iodo-propane 
• 17215-80-4 2-chloro-1-tetralone 
• 1068-55-9 isopropylmagnesium chloride 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 67-63-0 isopropyl alcohol 
• 75-26-3 isopropyl bromide 

Downstream Products

• 20175-89-7 2-isopropyl-1,4-naphthoquinone 
• 78507-00-3 2-Hydroxy-2-isopropyl-3,4-dihydro-2H-naphthalen-1-one 

Relevant academic research and scientific papers

Nickel-Catalyzed Hydrogen-Borrowing Strategy for α-Alkylation of Ketones with Alcohols: A New Route to Branched gem-Bis(alkyl) Ketones

The α-alkylation of ketones using an earth-abundant and nonprecious NiBr2/L1 system is reported. This nickel-catalyzed reaction could be performed in gram scale and successfully applied in the synthesis of donepezil (Alzheimer's drug) and functionalization of steroid hormones and fatty acid derivatives. Synthesis of N-heterocycles, methylation of ketones, and one-pot double alkylation to bis-hetero aryl ketones using two different alcohols with a single catalyst broadens the scope of the catalytic protocol. Preliminary mechanistic studies using defined Ni-H species and deuterium-labeling experiments established the participation of the borrowing-hydrogen strategy.

Catalytic cross-coupling of alkylzinc halides with α-chloroketones

The cross-coupling of alkylzinc halides with α-chloroketones catalyzed by Cu(acac)2 is described. Using this method, primary and secondary alkyl groups are introduced adjacent to a ketone carbonyl under mild reaction conditions and in good yield. Cyclic, acyclic, aromatic, and aliphatic α-chloroketones are suitable substrates. Optically active α-chloroketones are converted to optically active products. The reaction was found to proceed stereospecifically with inversion of stereochemistry. The reaction is proposed to occur by direct substitution of the chloride with the alkyl group of an organocopper, -magnesium, or -zinc species. Copyright

Synthetic utility of stannyl enolates as radical alkylating agents

(Equation presented) The radical-initiated β-ketoalkylation of haloalkanes with tributylstannyl enolates is described. Stannyl enolates derived from aromatic ketones are reactive toward the homolytic β-ketoalkylation of simple haloalkanes as well as those activated by an electron-withdrawing group. The reactivity of stannyl enolates as radical alkylating agents can be utilized for an efficient three-component coupling reaction among stannyl enolates, haloalkanes, and electron-deficient alkenes.

Studies on stereoselective electrophilic cyanation

The enantioselective, electrophilic cyanation of the enolates of 2-substituted 1-tetralones 3 is described. Enantiomerically pure 2-cyanato-1,1′-binaphthyl derivatives 2, 6a and b are used as cyanating agents. The influence of solvent, temperature, additives and the method of enolate formation are investigated. Best results are obtained with 48% ee in the case of compound 2 and 60% ee in the case of compound 6b if the enolate is prepared from the corresponding silyl enol ether 7 and Toluene is used as solvent.