41840-94-2

Usage

Uses

Used in Illicit Drug Market:
Ethanone, 2-(2-chlorophenyl)-1-(4-methylphenyl)is used as a psychoactive substance in the illicit drug market for its ability to induce euphoria, increased energy, and enhanced perception. Its effects are similar to other stimulants, making it a popular choice among users seeking a temporary high.
Used in Research and Forensic Analysis:
In the field of research and forensic analysis, Ethanone, 2-(2-chlorophenyl)-1-(4-methylphenyl)is used for studying the effects of synthetic stimulants on the human body and developing methods for their detection and identification. Understanding the chemical properties and potential health risks associated with Ethanone, 2-(2-chlorophenyl)-1-(4-methylphenyl)- can help in the development of strategies to combat its abuse and inform public health policies.
Used in Drug Control and Regulation:
Ethanone, 2-(2-chlorophenyl)-1-(4-methylphenyl)is used as a reference compound in the development and implementation of drug control and regulation policies. Its classification as a controlled substance in many countries highlights the need for strict regulations and monitoring to prevent its abuse and mitigate the associated health risks.

Upstream product

• 2444-36-2 2'-chloro-benzeneacetic acid 
• 108-88-3 toluene 
• 5142-75-6 tri(p-tolyl)bismuth 
• 51512-09-5 2-(2-chlorophenyl)acetyl chloride 

Downstream Products

• 1370409-56-5 2-(2-chlorophenyl)-3-(4-methylphenyl)-5-nitroimidazo[2,1-b][1,3]benzothiazole 
• 1370024-75-1 2-(2-chlorophenyl)-3-(4-methylphenyl)-2,3-dihydroimidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid 
• 343596-14-5 C₁₅H₁₂BrClO 
• 41841-00-3 1-(2-chlorophenyl)-2-(4-methylphenyl)ethyldione 

Relevant academic research and scientific papers

Synthesis and preliminary in-vitro cytotoxic activity of novel substituted diaryl-imidazo [2, 1, b]-benzothiazole derivatives

A novel series of substituted diaryl imidazo[2, 1-b]benzothiazole derivatives (8a-y) were synthesized by condensation reaction between 2-amino benzothiazole derivatives (3a-g) and substituted a-bromo-1, 2-(substituted) diaryl-1-ethanones (7a-i). The structures of the synthesized compounds were established by IR, 1H NMR, 13C NMR and mass spectroscopical data. The compounds (8a-y) were evaluated for their in-vitro cytotoxic activity on murine (B16F10) and human (MCF-7) cancer cells by using MTT assay. From the in vitro studies compounds 8p, 8u and 8y were found most effective with an IC50 range of 0.56-27.50 μM in MCF-7 and 2.57-36.54 μM in B16F10 cells.

Synthesis and preliminary in-vitro cytotoxic activity of novel substituted diaryl-imidazo [2,1,b]-benzothiazole derivatives

A novel series of substituted diaryl imidazo[2,1-b]benzothiazole derivatives (8a-y) were synthesized by condensation reaction between 2-amino benzothiazole derivatives (3a-g) and substituted α-bromo-1, 2-(substituted) diaryl-1-ethanones (7a-i). The structures of the synthesized compounds were established by IR, 1H NMR, 13C NMR and mass spectroscopical data. The compounds (8a-y) were evaluated for their in-vitro cytotoxic activity on murine (B16F10) and human (MCF-7) cancer cells by using MTT assay. From the in vitro studies compounds 8p, 8u and 8y were found most effective with an IC50 range of 0.56-27.50 μM in MCF-7 and 2.57-36.54 μM in B16F10 cells.

Synthesis of (2-chlorophenyl)(phenyl)methanones and 2-(2-chlorophenyl)-1- phenylethanones by Friedel-Crafts acylation of 2-chlorobenzoic acids and 2-(2-chlorophenyl)acetic acids using microwave heating

Several 2-(2-chlorophenyl)-1-phenylethanones and (2-chlorophenyl)(phenyl) methanones were prepared by the Friedel-Crafts acylation reaction of 2-(2-chlorophenyl) acetic acids and 2-chlorocarboxylic acids, respectively, in the presence of cyanuric chloride, pyridine, and AlCl3 or FeCl 3 using microwave heating. The yields of the ketones were significantly higher than those obtained using conventional heating. In addition, similar reactions carried out with the less inexpensive and less toxic FeCl3 gave titled ketones in comparable yields. Interestingly, the FeCl3 catalyzed reactions gave pure ketones (no chromatographic purification required), whereas the AlCl3 catalyzed reaction gave impure product that required chromatographic purification.

Pd-catalyzed synthesis of α-aryl ketones through couplings of α-arylacetyl chlorides with triarylbismuths as multi-coupling nucleophiles

The cross-coupling reaction of α-arylacetyl chlorides with triarylbismuths was studied under Pd-catalyzed conditions. The reaction was found to be facile under the established protocol and furnished high yields of α-aryl ketones in short reaction times. T

An efficient and time saving microwave-assisted selenium dioxide oxidation of 1,2-diarylethanones

Selenium dioxide oxidation of 1,2-diarylethanones to corresponding diones by conventional method takes upto 8 hr. The same oxidation under microwave radiations using dimethylsulfoxide as solvent reduces the reaction time considerably (30 to 90 sec). The method reported is efficient and time saving.