41841-19-4

Upstream product

• 67-56-1 methanol 
• 4408-60-0 2-mesitylacetic acid 
• 50690-12-5 2-chloro-1-(2,4,6-trimethyl-phenyl)-ethanone 
• 108-67-8 1,3,5-trimethyl-benzene 
• 487-68-3 mesytaldehyde 
• 77295-61-5 1,1-Dibrom-2-(2,4,6-trimethylphenyl)ethylen 

Downstream Products

• 4408-60-0 2-mesitylacetic acid 
• 1255943-90-8 4-hydroxy-8-methoxy-3-(2,4,6-trimethyl-phenyl)-1-oxa-8-aza-spiro[4.5]dec-3-en-2-one 
• 1256917-24-4 3-[1-methoxy-4-(4-methoxy-benzylsulfanyl)-piperidin-4-yl]-3-oxo-2-(2,4,6-trimethyl-phenyl)-propionic acid methyl ester 
• 94265-41-5 2-(2,4,6-Trimethyl-phenyl)-ethyl-p-toluolsulfonat 
• 6950-92-1 2-(2,4,6-trimethylphenyl)ethanol 
• 1208109-83-4 1'-(2-mesitylethyl)-6-methoxy-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride 
• 1612831-46-5 methyl 2-mesityl-3-oxobutanoate 
• 1612831-44-3 C₃₀H₄₂F₃NO₄SSi 
• 1612831-55-6 methyl 5-hydroxy-2-mesityl-5-methyl-3-oxo-7-(4-(trifluoromethyl) phenylthio)heptanoate 
• 1612831-54-5 methyl 5-hydroxy-2-mesityl-3-oxo-6-(phenylthio)hexanoate 
• 1612831-53-4 methyl 5-hydroxy-2-mesityl-3-oxo-8-(phenylthio)octanoate 
• 1612831-52-3 methyl 5-hydroxy-2-mesityl-3-oxo-7-(4-(trifluoromethyl)phenoxy)heptanoate 
• 1612830-39-3 C₂₃H₂₆O₃S 
• 1612831-51-2 5-mesityl-2-(1-(methylsulfonyloxy)propan-2-yl)-6-oxo-3,6-dihydro-2H-pyran-4-yl pivalate 

Relevant academic research and scientific papers

Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-ones as potassium-competitive acid blockers

With the aim to discover a gastric antisecretory agent more potent than the existing proton pump inhibitors, novel 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-one derivatives, which could occupy two important lipophilic pockets (described as LP-1 and LP-2) of H+,K+-ATPase and can strongly bind to the K+-binding site, were designed based on a docking model. Among the compounds synthesized, compound 4d showed a strong H+,K+-ATPase-inhibitory activity and a high stomach concentration in rats, resulting in potent inhibitory action on histamine-stimulated gastric acid secretion in rats. Furthermore, 4d exerted significant inhibitory action on histamine-stimulated gastric-acid secretion in rats with a rapid onset and moderate duration of action after the administration. These findings may lead to a new insight into the drug design of potassium-competitive acid blockers.

Synthesis of Ketones and Esters from Heteroatom-Functionalized Alkenes by Cobalt-Mediated Hydrogen Atom Transfer

Cobalt bis(acetylacetonate) is shown to mediate hydrogen atom transfer to a broad range of functionalized alkenes; in situ oxidation of the resulting alkylradical intermediates, followed by hydrolysis, provides expedient access to ketones and esters. By modification of the alcohol solvent, different alkyl ester products may be obtained. The method is compatible with a number of functional groups including alkenyl halides, sulfides, triflates, and phosphonates and provides a mild and practical alternative to the Tamao-Fleming oxidation of vinylsilanes and the Arndt-Eistert homologation.

NOVEL BETA MIMETICS WITH EXTENDED DURATION OF ACTION, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS

The invention relates to compounds of general formula (I), where the groups R1, R2 and R3 can have the meanings given in the claims and the description, method for production and use thereof as medicaments, in particular for the treatment of inflammatory and obstructive bronchial diseases.

Spirodiclofen and spiromesifen - Novel acaricidal and insecticidal tetronic acid derivatives with a new mode of action

The broad spectrum acaricides spirodiclofen (BAJ2740, trade name: Envidor) and spiromesifen (BSN2060, trade name: Oberon) with an additional excellent activity against whiteflies, both belong to the new chemical class of tetronic acid derivatives discovered at Bayer CropScience during the 1990s. The discovery process starting from herbicidal PPO (protoporphyrinogen oxidase) chemistry, the synthetic routes leading to the products, and some insight into process development of central intermediates is given. Spirodiclofen and spiromesifen have a new mode of action (interference with lipid biosynthesis), show no cross-resistance to any resistant mite or whitefly field population and are therefore valuable tools for resistance management.

Unusual Kinetic Stability of Enols to Ketonization: 1,2-Dimesityl-3-methylbut-1-en-1-ol and Related β-Alkyl-α,β-dimesitylethenols

The β-alkyl-α,β-dimesitylethenols 3 and the isomeric β-alkyl-α,β-dimesitylethanones 4 (β-alkyl = Me, Et, i-Pr) were prepared and their spectral properties are reported.X-ray diffraction of the β-isopropyl enol 3d showed that the two mesityl rings are near

Photoenolization with α-Chloro Substituents

Irradiation of a methanol solution of 2,5-dimethyl-α-chloropropiophenone (1a) produces 2,6-dimethyl-1-indanone (2a), 2-(methoxymethyl)-5-methylpropiophenone (3a), 2,5-dimethylpropiophenone (4a), and methyl 2-(2,5-dimethylphenyl)propionate (5a).It is proposed that the first two products arise from hydrogen abstraction followed by chlorine loss, the latter two from initial loss of chlorine.Making the chlorine-bearing carbon primary suppresses the formation of the latter two products, while maintaining the carbonyl nearly planar with the ring suppresses all product formation.Other examples are presented.