41862-17-3Relevant articles and documents
Construction of Dihydropyrido[2,3- d]pyrimidine Scaffolds via Aza-Claisen Rearrangement Catalyzed by N-Heterocyclic Carbenes
Dzieszkowski, Krzysztof,Barańska, Izabela,Rafiński, Zbigniew
, p. 6645 - 6662 (2020/07/14)
N-Heterocyclic carbenes (NHCs) catalyzing aza-Claisen rearrangement of α,β-unsaturated enals with cyclic vinylogous amides under oxidative conditions generating potentially biologically active dihydropyridinone-fused uracils have been developed. This strategy represents a unique NHC-activation-based path with the use of 6-aminouracils as stable α,β-diEWG cyclic vinylogous amides for the efficient synthesis of bicyclic N-unprotected lactams similar to those in many useful drugs.
A heterocyclic molecule with significant activity against dengue virus
Nair, Vasu,Chi, Guochen,Shu, Qingning,Julander, Justin,Smee, Donald F.
scheme or table, p. 1425 - 1427 (2009/10/02)
There are no specific approved drugs or vaccines for the treatment or prevention of infectious dengue virus and there are very few compounds known that inhibit the replication of this virus. This letter describes the concise synthesis of two uracil-based
