41876-46-4

Basic information

• Product Name: <4-hydroxy-3-(methoxycarbonyl)phenyl>phenylmethane
• CAS NO: 41876-46-4
• Molecular Weight: 242.274
• Mol File: 41876-46-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: <4-hydroxy-3-(methoxycarbonyl)phenyl>phenylmethane(CAS DataBase Reference)
• NIST Chemistry Reference: <4-hydroxy-3-(methoxycarbonyl)phenyl>phenylmethane(41876-46-4)
• EPA Substance Registry System: <4-hydroxy-3-(methoxycarbonyl)phenyl>phenylmethane(41876-46-4)

Safety Data

• Hazardous Substances Data: 41876-46-4(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 119-36-8 methyl salicylate 
• 100-52-7 benzaldehyde 
• 89-55-4 5-bromosalicyclic acid 
• 186581-53-3 diazomethane 
• 4386-41-8 5-benzyl-2-hydroxy-benzoic acid 
• 38632-84-7 benzyl benzenesulfonate 

Downstream Products

• 4386-41-8 5-benzyl-2-hydroxy-benzoic acid 

Relevant articles and documents

Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs

A series of compounds containing one or two salicylic acid moieties were synthesized, and their efficacy to inhibit the phosphohydrolase activity of PTP1B examined. Some of the methylenedisalicylic acid derivatives were potent inhibitors of PTP1B. Of those derivatives, 3c exhibited about a 14-fold selectivity against TC-PTP, and this compound was tested in a mouse model for its efficacy to prevent diet-induced obesity. It effectively suppressed the increases in body weight and adipose mass, without any noticeable toxic effect. The compound also prevented increases in the plasma triglyceride, cholesterol, and nonesterified fatty acid concentrations; thus, expanding its therapeutic potential to other related metabolic diseases, such as hyperlipidemia and hypercholesterolemia.