41894-76-2

Usage

Uses

Used in Pharmaceutical Synthesis:
Bicyclo[4.1.0]heptane-7-carboxylic acid serves as a building block in the synthesis of pharmaceuticals, contributing to the development of various medications due to its unique structural properties.
Used in Agrochemical Production:
bicyclo[4.1.0]heptane-7-carboxylic acid is also utilized as a building block in the synthesis of agrochemicals, playing a role in the creation of substances that help protect and enhance crop yields.
Used in Fragrance Industry:
Bicyclo[4.1.0]heptane-7-carboxylic acid is employed in the fragrance industry, capitalizing on its distinctive camphor-like scent to contribute to the formulation of various perfumes and scented products.
Used as a Chemical Intermediate in Polymer and Plastics Production:
Bicyclo[4.1.0]heptane-7-carboxylic acid is used as a chemical intermediate in the production of polymers and plastics, where its stability and versatility are advantageous in creating durable and functional materials.

Upstream product

• 52917-64-3 ethyl 7-norcaranecarboxylate 
• 201230-82-2 carbon monoxide 
• 2415-79-4 7,7-dibromonorcarane 
• 110-83-8 cyclohexene 
• 10330-36-6 exo-7-acetylbicyclo<4.1.0>heptane 

Downstream Products

• 10330-36-6 exo-7-acetylbicyclo<4.1.0>heptane 
• 13830-44-9 7-'exo'-Hydroxy-bicyclo<4.1.0>heptan 
• 84322-60-1 Bicyclo<4.1.0>heptane-7-carbonyl chloride 

Relevant academic research and scientific papers

Chemical trigger-enabled bioconjugation reaction

Development of conceptually novel and practically useful bioconjugation reactions has been an intense pursuit of chemical biology research. Herein, we report an unprecedented bioconjugation reaction that hinges on a chemical trigger-enabled inverse-electron-demand Diels-Alder (IEDDA) cycloaddition oftrans-cycloheptene (TCH) with tetrazine. Unlike the conventional strain-promoted bioconjugation reactions that utilize built-in strained alkenes as reactants, the current one features a “trigger-release-conjugate” reaction model, in which a highly strained TCH species is released from a bench-stable bicyclicN-nitrosourea (BNU) derivative upon treatment with an external stimulus. It is noteworthy that the reactivity-stability balance of BNU derivatives could be tuned by manipulating their N-1 substituents. As a proof-of-concept case, this new chemical trigger-enabled IEDDA reaction has been applied toin vitroprotein labeling and pretargeted cell imaging. This work opens a new avenue to utilize BNU derivatives as a new class of chemical reporters in bioconjugate chemistry.

Bicyclo[4.1.0]heptane nitrosourea derivative for biological orthogonal reaction, and preparation method and application thereof

The invention discloses a bicyclo[4.1.0]heptane nitrosourea derivative for a biological orthogonal reaction, and a preparation method and an application thereof. The structural formula of the bicyclo[4.1.0]heptane nitrosourea derivative is represented by

Metal catalyzed carbonylation of gem-dibromocyclopropanes

The first examples of the catalytic carbonylation of gem-dibromocyclopropanes is described, using cobalt and nickel salts as catalysts under phase transfer conditions.