84322-60-1

Upstream product

• 41894-76-2 bicyclo[4.1.0]heptane-7-carboxylic acid 
• 110-83-8 cyclohexene 
• 52917-64-3 ethyl 7-norcaranecarboxylate 

Downstream Products

• 100717-56-4 (1r)-norcarane-7c-carbanilide 
• 38117-54-3 cyclopentadienyl iron(II) dicarbonyl dimer 
• 84206-03-1 dicarbonyl-η5-cyclopentadienyl(bicyclo[4.1.0]hepta-7-ylcarbonyl)iron 

Relevant academic research and scientific papers

Chemical trigger-enabled bioconjugation reaction

Development of conceptually novel and practically useful bioconjugation reactions has been an intense pursuit of chemical biology research. Herein, we report an unprecedented bioconjugation reaction that hinges on a chemical trigger-enabled inverse-electron-demand Diels-Alder (IEDDA) cycloaddition oftrans-cycloheptene (TCH) with tetrazine. Unlike the conventional strain-promoted bioconjugation reactions that utilize built-in strained alkenes as reactants, the current one features a “trigger-release-conjugate” reaction model, in which a highly strained TCH species is released from a bench-stable bicyclicN-nitrosourea (BNU) derivative upon treatment with an external stimulus. It is noteworthy that the reactivity-stability balance of BNU derivatives could be tuned by manipulating their N-1 substituents. As a proof-of-concept case, this new chemical trigger-enabled IEDDA reaction has been applied toin vitroprotein labeling and pretargeted cell imaging. This work opens a new avenue to utilize BNU derivatives as a new class of chemical reporters in bioconjugate chemistry.

Bicyclo[4.1.0]heptane nitrosourea derivative for biological orthogonal reaction, and preparation method and application thereof

The invention discloses a bicyclo[4.1.0]heptane nitrosourea derivative for a biological orthogonal reaction, and a preparation method and an application thereof. The structural formula of the bicyclo[4.1.0]heptane nitrosourea derivative is represented by

Novel indolobenzazepine derivatives, useful as tranquilizers

Certain novel 1,2,3,4,8,9-hexahydro-3-(substituted)pyrido[4',3':2,3]indolo[1,7-ab][1]-benzazepines are useful as minor tranquilizers (anxiolytics) and/or major tranquilizers (antipsychotics). The minor tranquilizers are effective at non-ataxic doses, and are not likely to cause addiction when abused. A representative compound in this class is 3-(cyclopropylmethyl)-1,2,3,4,8,9-hexahydropyrido[4',3':2,3]indolo[1,7-ab][1]benzazepine.