41913-82-0

Basic information

• Product Name: 5-Tosyloxy-2,2-ethylenedioxypentane
• Synonyms: 5-Tosyloxy-2,2-ethylenedioxypentane
• CAS NO: 41913-82-0
• Molecular Weight: 300.376
• Mol File: 41913-82-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-Tosyloxy-2,2-ethylenedioxypentane(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Tosyloxy-2,2-ethylenedioxypentane(41913-82-0)
• EPA Substance Registry System: 5-Tosyloxy-2,2-ethylenedioxypentane(41913-82-0)

Safety Data

• Hazardous Substances Data: 41913-82-0(Hazardous Substances Data)

Upstream product

• 20449-21-2 2-(but-3-en-1-yl)-2-methyl-1,3-dioxolane 
• 539-88-8 4-oxopentanoic acid ethyl ester 
• 941-43-5 Ethyl levulinate ethylene ketal 
• 5185-97-7 4-oxopentyl acetate 
• 29021-95-2 1-acetoxy-3-(2-methyl-[1,3]dioxolan-2-yl)-propane 
• 29021-98-5 3-(2-methyl-[1,3]dioxolan-2-yl)-propan-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

Potentiation of cADPR-induced Ca2+-release by methylxanthine analogues

Caffeine and other methylxanthines are known to induce Ca2+-release from intracellular stores via the ryanodine receptor. In the present work, a range of caffeine analogues, in which methyl groups at the 1 and 7 positions were replaced with alkyl chains containing different functional groups (oxo, hydroxyl, propargyl, ester, and acids), were synthesized. These compounds were then screened for their ability to potentiate Ca2+-release induced by cADPR (an endogenous modulator of ryanodine receptors) in sea urchin egg homogenates. Two of the synthesized methylxanthines, 1,3-dimethyl-7-(7- hydroxyoctyl)xanthine (37) and 3-methyl-7-(7-oxooctyl)-1-propargylxanthine (66), were shown to be more potent than caffeine in potentiating cADPR- induced Ca2+-release, while 1,3-dimethyl-7-(5-ethylcarboxypentyl)xanthine (14) was shown to be more efficacious. The development of new methylxanthine analogues may lead to a better understanding of ryanodine receptor function and could possibly provide novel therapeutic agents.

INSECT PHEROMONES AND THEIR ANALOGS. XLVII. SYNTHESIS OF 11-OXODODECA-3,6-DIYNOIC ACID - THE ACYCLIC PRECURSOR OF A MACROLIDE COMPONENT OF PHEROMONES OF Oryzaephilus mercator AND O. surinamensis

A new approach is proposed to the synthesis of 11-oxododeca-3,6-diynoic acid - the acyclic precursor of a macrolide component of pheromones of Oryzaephilus mercator and O. surinamensis - from the readily available tetrahydropyran or allylacetone via the intermediate 5-bromo-2,2-ethylenedioxypentane.