41927-58-6

Upstream product

• 77-78-1 dimethyl sulfate 
• 30588-33-1 5-hydroxy-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 88585-32-4 4-ethoxycarbonyl-1-phenyl-3-pyrazolin-5-one 
• 333-27-7 methyl trifluoromethanesulfonate 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 88585-33-5 1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid 

Relevant academic research and scientific papers

SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

NMR spectroscopic investigations with ethyl 1-(hetero)aryl-5-hydroxy-1H-pyrazole-4-carboxylates.

The synthesis of a series of ethyl N-1-(hetero)aryl-5-hydroxy-1H-pyrazole-4-carboxylates by reaction of diethyl ethoxymethylenemalonate with appropriate hydrazines is described.According to nmr-spectroscopic investigations (1H- and 13C-nmr) the title compounds exist as 5-hydroxy tautomers in deuteriochloroform as well as in deuteriodimethyl sulfoxide solution.