30588-33-1Relevant academic research and scientific papers
An unusual thionyl chloride-promoted c?c bond formation to obtain 4,4'-bipyrazolones
Eller, Gernot A.,Vilkauskaite, Gyt?,Sa?kus, Algirdas,Martynaitis, Vytas,Mamuye, Ashenafi Damtew,Pace, Vittorio,Holzer, Wolfgang
supporting information, p. 1287 - 1292 (2018/06/13)
Dialkyl 5,5'-dioxo-4,4'-bipyrazole-4,4'-dicarboxylates are readily obtained by the reaction of 5-hydroxypyrazole-4-carboxylates in refluxing thionyl chloride. The obtained diesters can be transformed into the corresponding 4,4'-bipyrazoles via alkaline hy
Novel Heterocyclic Compound Classes for Signaling Modulation
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Paragraph 0221; 0222, (2015/11/24)
The invention relates to compounds of Formulas I-VII (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their use in manufactures and methods for modulating cellular signaling pathways and biological
Microwave-assisted direct amidation of ethyl 1-phenyl-5-hydroxy-1H-pyrazole-4-carboxylate
Milo?evic, Mladena,?terbal, Ines,Fegu?, Urban,Ba?kov?, Jernej,Prek, Benjamin,Gro?elj, Uro?,Stanovnik, Branko,Svete, Jurij
, p. 556 - 561 (2015/04/14)
Microwave-assisted treatment of ethyl 5-hydroxy-1-phenyl-1H-pyrazole-4-carboxylate with excess primary aliphatic amines in 1-propanol at 140C and with excess pyrrolidine or piperidine in 2-methoxyethanol at 180C produced the corresponding carboxamides in
NMR spectroscopic investigations with ethyl 1-(hetero)aryl-5-hydroxy-1H-pyrazole-4-carboxylates.
Holzer, Wolfgang,Schmid, Eva
, p. 1341 - 1350 (2007/10/02)
The synthesis of a series of ethyl N-1-(hetero)aryl-5-hydroxy-1H-pyrazole-4-carboxylates by reaction of diethyl ethoxymethylenemalonate with appropriate hydrazines is described.According to nmr-spectroscopic investigations (1H- and 13C-nmr) the title compounds exist as 5-hydroxy tautomers in deuteriochloroform as well as in deuteriodimethyl sulfoxide solution.
