41940-16-3Relevant academic research and scientific papers
One-step synthesis of 1,4-bis(het)arylisoquinolines by the reaction of 1,2,4-triazines with arynes
Kopchuk, Dmitry S.,Nikonov, Igor L.,Khasanov, Albert F.,Gundala, Sravya,Krinochkin, Alexey P.,Slepukhin, Pavel А.,Zyryanov, Grigory V.,Venkatapuram, Padmavathi,Chupakhin, Oleg N.,Charushin, Valery N.
, p. 978 - 984 (2019/11/16)
[Figure not available: see fulltext.] The reaction of 3,6-bis(het)aryl-1,2,4-triazines (hetaryl ≠ 2-pyridyl) with aryne intermediates generated in situ was studied. As a result, novel 1,4-bis(het)arylisoquinolines were synthesized with yields of up to 45%. The main rules of the reactions were studied, and the obtained experimental data were compared with those described in the literature.
One-Pot Acid-Catalyzed Ring-Opening/Cyclization/Oxidation of Aziridines with N-Tosylhydrazones: Access to 1,2,4-Triazines
Crespin, Lorène,Biancalana, Lorenzo,Morack, Tobias,Blakemore, David C.,Ley, Steven V.
supporting information, p. 1084 - 1087 (2017/03/15)
A new, three-step, telescoped reaction sequence for the regioselective conversion of N-tosyl hydrazones and aziridines to 3,6-disubstituted and 3,5,6-trisubstituted 1,2,4-triazines is described. The process involves an efficient nucleophilic ring opening of the aziridine, giving access to a wide range of aminohydrazones, isolated with excellent yields. A “one-pot” procedure, combining the ring opening with a cyclization and an oxidation step, allows the preparation of diversified triazines in good yields.
Novel one pot synthesis of substituted 1,2,4-triazines
Nongkhlaw, Rishan Lang,Myrboh, Bekington
, p. 67 - 72 (2007/10/03)
Substituted-1,2,4-triazines were conveniently prepared in one pot by the condensation of amides and 1,2-diketones in presence of base, followed by cyclisation with hydrazine hydrate.
Studies on as-Triazine Derivatives. XII. Synthesis of Alkenyl-1,2,4-triazine Derivatives
Konno, Shoetsu,Sagi, Mataichi,Takaharu, Etsuko,Fujimura, Satoshi,Hayashi, Kazuhiko,Yamanaka, Hiroshi
, p. 1721 - 1726 (2007/10/02)
3-Methyl-5,6-diphenyl-1,2,4-triazine (1) was treated with chlorine to give 3-trichloromethyl-5,6-diphenyl-1,2,4-triazine (2) as a sole product.On treatment with an excess (4.5 mol eq) of triphenylphosphine, 2 was transformed into α-(5,6-diphenyl-1,2,4-tri
STUDIES ON as-TRIAZINE DERIVATIVES. IV. SYNTHESIS OF UNSYMMETRICAL 5,6-DISUBSTITUTED 1,2,4-TRIAZINES
Konno, Shoetsu,Sagi, Mataichi,Agata, Mitsuko,Aizawa, Yuichi,Yamanaka, Hiroshi
, p. 2241 - 2244 (2007/10/02)
The reaction of 5-chloro-6-methyl-3-phenyl-1,2,4-triazine (4a) with ethylidenetriphenylphosphorane followed by the hydrolysis of the resulting as-triazinylphosphorane afforded 5-ethyl-6-methyl-3-phenyl-1,2,4-triazine (6a) in 88 percent yield.The condensat
