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Tolimidone, also known as MLR-1023, is an allosteric activator of Lyn kinase with an EC50 of 63 nM. It is a promising pharmaceutical candidate with no significant activity against a panel of related kinases. Tolimidone is orally bioavailable and has been shown to reduce blood glucose levels in mice, particularly in an insulin-dependent manner, by increasing insulin receptor sensitivity. Tolimidone produces a dose-dependent and durable glucose-lowering effect in chronically treated db/db mice without causing weight gain.

41964-07-2

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41964-07-2 Usage

Uses

Used in Pharmaceutical Industry:
Tolimidone is used as an insulin receptor-potentiating agent for its ability to reduce blood glucose levels in mice. It has been shown to be effective in increasing insulin receptor sensitivity, which makes it a potential candidate for the treatment of type 2 diabetes.
Used in Diabetes Treatment:
Tolimidone is used as a glucose-lowering agent for its durable and dose-dependent effect in reducing blood glucose levels. It has the potential to be a valuable treatment option for diabetic patients, as it can help manage blood glucose levels without causing weight gain.

Check Digit Verification of cas no

The CAS Registry Mumber 41964-07-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,9,6 and 4 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 41964-07:
(7*4)+(6*1)+(5*9)+(4*6)+(3*4)+(2*0)+(1*7)=122
122 % 10 = 2
So 41964-07-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H10N2O2/c1-8-3-2-4-9(5-8)15-10-6-12-11(14)13-7-10/h2-7H,1H3,(H,12,13,14)

41964-07-2 Well-known Company Product Price

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  • Sigma

  • (SML0371)  MLR-1023  ≥98% (HPLC)

  • 41964-07-2

  • SML0371-5MG

  • 776.88CNY

  • Detail

  • Sigma

  • (SML0371)  MLR-1023  ≥98% (HPLC)

  • 41964-07-2

  • SML0371-25MG

  • 3,149.64CNY

  • Detail

41964-07-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(3-methylphenoxy)-1H-pyrimidin-2-one

1.2 Other means of identification

Product number -
Other names QCR-285

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:41964-07-2 SDS

41964-07-2Downstream Products

41964-07-2Relevant academic research and scientific papers

METHOD FOR PREPARING TOLIMIDONE ON LARGE SCALE

-

Paragraph 78-89, (2019/08/20)

The present disclosure relates to a method for preparing tolimidone on large scale with maintaining high purity and uniform particle size distribution, and more specifically, a method suitable for preparing tolimidone on industrially large scale by using

METHOD FOR PREPARING TOLIMIDONE ON LARGE SCALE

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Paragraph 0074; 0075, (2018/04/13)

The present invention relates to a method for preparing tolimidone maintaining high purity and uniform particle distribution on a large scale. According to the present invention, high-purity tolimidone can be manufactured in a short time when compared to existing technologies while keeping the moisture content and grain size distribution constant by using a tetrabutylammonium bromide catalyst and ethanol recrystallization. Therefore, the method is suitable for industrial mass production.(AA) Before recrystallization(BB) After recrystallizationCOPYRIGHT KIPO 2018

Bronchodilator and Antiulcer Phenoxypyrimidinones

Lipinski, C. A.,Stam, J. G.,Pereira, J. N.,Ackerman, N. R.,Hess, H.-J.

, p. 1026 - 1031 (2007/10/02)

Series of 5-phenoxy-2(1H)-pyrimidinones, 5-phenoxy-4(3H)-pyrimidinones, and related compounds were prepared in a follow-up of a lead prepared as a potential cyclic nucleotide regulating agent.Compounds were evaluated for bronchodilator activity in histamine-challenged guinea pigs and for antiulcer activity in a cold-restraint, stressed rat ulcer model.Bronchodilator activity comparable to, or greater than, that of theophylline was found in both the 2(1H)- and 4(3H)-pyrimidinone series and was most prominent in analogues containing either an electron-withdrawing or -donating substituent in the para position of the phenoxy ring.Significant antiulcer activity was observed only in the 2(1H)-pyrimidinone series among three closely related analogues.One of these, 5-(m-methylphenoxy)-2(1H)-pyrimidinone (3), exhibited more potent antiulcer effects than the clinically useful antiulcer agent carbenoxolone, without demonstrating bronchodilator activity.

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