53341-46-1

Basic information

• Product Name: (E)-3-(diMethylaMino)-2-(M-tolyloxy)acrylaldehyde
• Synonyms: (E)-3-(diMethylaMino)-2-(M-tolyloxy)acrylaldehyde
• CAS NO: 53341-46-1
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.253
• Mol File: 53341-46-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-3-(diMethylaMino)-2-(M-tolyloxy)acrylaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(diMethylaMino)-2-(M-tolyloxy)acrylaldehyde(53341-46-1)
• EPA Substance Registry System: (E)-3-(diMethylaMino)-2-(M-tolyloxy)acrylaldehyde(53341-46-1)

Safety Data

• Hazardous Substances Data: 53341-46-1(Hazardous Substances Data)

Usage

General Description

(E)-3-(diMethylaMino)-2-(M-tolyloxy)acrylaldehyde, also known as "DMAOTA," is a chemical compound with the molecular formula C12H15NO2. It is a yellow crystalline solid that is commonly used as an intermediate in the synthesis of dyes and pharmaceuticals. DMAOTA is also used as a reagent in organic synthesis and as a fluorescent probe for biological imaging. It is important to handle DMAOTA with care, as it is a potentially hazardous chemical that should be used in a well-ventilated area and with appropriate protective equipment. Additionally, DMAOTA has been identified as a potential skin and eye irritant, and exposure should be avoided.

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Relevant articles and documents

METHOD FOR PREPARING TOLIMIDONE ON LARGE SCALE

The present disclosure relates to a method for preparing tolimidone on large scale with maintaining high purity and uniform particle size distribution, and more specifically, a method suitable for preparing tolimidone on industrially large scale by using

Bronchodilator and Antiulcer Phenoxypyrimidinones

Series of 5-phenoxy-2(1H)-pyrimidinones, 5-phenoxy-4(3H)-pyrimidinones, and related compounds were prepared in a follow-up of a lead prepared as a potential cyclic nucleotide regulating agent.Compounds were evaluated for bronchodilator activity in histamine-challenged guinea pigs and for antiulcer activity in a cold-restraint, stressed rat ulcer model.Bronchodilator activity comparable to, or greater than, that of theophylline was found in both the 2(1H)- and 4(3H)-pyrimidinone series and was most prominent in analogues containing either an electron-withdrawing or -donating substituent in the para position of the phenoxy ring.Significant antiulcer activity was observed only in the 2(1H)-pyrimidinone series among three closely related analogues.One of these, 5-(m-methylphenoxy)-2(1H)-pyrimidinone (3), exhibited more potent antiulcer effects than the clinically useful antiulcer agent carbenoxolone, without demonstrating bronchodilator activity.