41969-31-7

Upstream product

• 127391-41-7 2-((E)-2-Phenyl-but-1-en-3-ynyl)-pyridine 1-oxide 
• 127391-40-6 2-((Z)-2-Phenyl-but-1-en-3-ynyl)-pyridine 1-oxide 
• 1658-42-0 methyl 2-pyridylacetate 
• 536-74-3 phenylacetylene 
• 41969-30-6 methyl 4-oxo-2-phenyl-4H-quinolizine-1-carboxylate 
• 98-88-4 benzoyl chloride 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 1620-53-7 1-phenyl-2-pyridin-2-ylethanone 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Relevant academic research and scientific papers

From CO2 to 4 H-Quinolizin-4-ones: A One-Pot Multicomponent Approach via Ag2O/Cs2CO3 Orthogonal Tandem Catalysis

Using carbon dioxide as a C1 precursor, here we report relatively simple and cost-effective orthogonal tandem catalysis, namely Ag2O in conjunction with Cs2CO3 serves to promote a multicomponent tandem reaction forming two new C-C and one new C-N bonds. 4H-Quinolizin-4-ones, key skeletal components in a variety of biologically active molecules, were obtained with yields up to 99%. The present approach features a broad substrate scope and mild reaction conditions and benefits from using cost-effective reaction and catalysts.

Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner-Wadsworth-Emmons olefination/cyclisation

4H-Quinolizin-4-ones are a unique class of heterocycle with valuable physicochemical properties and which are emerging as key pharmacophores for a range of biological targets. A tandem Horner-Wadsworth-Emmons olefination/cyclisation method has been developed to allow facile access to substituted 4H-quinolizin-4-ones encoded with a range of functional groups.

HETEROCYCLIC SYNTHESIS BY ELECTROCYCLIZATION OF EXTENDED DIPOLES: A NOVEL ACCESS TO THE INDOLIZINE AND QUINOLIZINE SYSTEMS

On thermal activation α-butenynyl substituted pyridine-N-oxides 4 undergo a multistep rearrangement affording 4-oxo-4H-quinolizines (8) and 2-acylindolizines (9).In the geometrical isomeriziation of E-4 to Z-4 annulated isoxazolidines (7) are involved as unstable intermediates.