41993-68-4

Usage

InChI:InChI=1/C14H19NO4/c1-4-19-14(16)13-10-8-12(18-3)11(17-2)7-9(10)5-6-15-13/h7-8,13,15H,4-6H2,1-3H3

Upstream product

• 13326-56-2 ethyl N-[2-(3,4-dimethoxyphenyl)ethyl]oxamate 
• 13326-57-3 ethyl 6,7-dimethoxy-3,4-dihydroisoquinoline-1-carboxylate 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 

Downstream Products

• 141735-96-8 6,7-Dimethoxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid cyclohexylidene-hydrazide 
• 141735-94-6 1-hydrazido-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 1253798-41-2 (1'R,3S,11bR)-2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl]-3-ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline 
• 1253798-35-4 (1'S,3S,11bR)-2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl]-3-ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline 
• 41143-95-7 6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid 
• 141736-01-8 (3S,10bS)-8,9-Dimethoxy-3-(4-nitro-phenyl)-2-{[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-amino}-2,3,6,10b-tetrahydro-5H-imidazo[5,1-a]isoquinolin-1-one 
• 141736-01-8 (3R,10bS)-8,9-Dimethoxy-3-(4-nitro-phenyl)-2-{[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-amino}-2,3,6,10b-tetrahydro-5H-imidazo[5,1-a]isoquinolin-1-one 
• 141736-00-7 (3R,10bS)-8,9-Dimethoxy-3-phenyl-2-{[1-phenyl-meth-(Z)-ylidene]-amino}-2,3,6,10b-tetrahydro-5H-imidazo[5,1-a]isoquinolin-1-one 
• 141735-98-0 C₂₄H₃₃N₃O₃ 
• 493-49-2 6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 206118-01-6 6,7-dimethoxy-N-(2,4,6-trimethylbenzoyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 486-99-7 (6,7-dimethoxy-1,2,3,4-tetrahydro-1-isoquinolyl)methanol 
• 206118-04-9 6,7-Dimethoxy-2-(2,4,6-trimethyl-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

First synthesis of thiazepino[3,4-a]isoquinolines, a facile new synthetic route to diazepino[3,4-a]isoquinolines and assessment of their dopamine and σ receptor affinities

Heterocycles that bear the novel 5,6,14,14a-tetrahydro-8H-benzo[6,7][1,4]thiazepino[3,4-a]isoquinoline and the 5,6,14,14a-tetrahydro-8H-13l2-benzo[6,7][1,4]diazepino[3,4-a]isoquinoline frameworks were synthesized in a facile manner. These tetrahydroprotoberberine (THPB)-inspired scaffolds demonstrate selective affinity for the σ1R in contrast to the naturally occurring THPB congeners that show D1R and σ2R selectivity.

Synthesis of bioactive 2-aza-analogues of ipecac and alangium alkaloids

License to kill: Substitution of the methine carbon C2 in the ipecac or alangium alkaloids by nitrogen yields functional mimetics with low micromolar to high naonomolar IC50 values against Trypanosoma brucei, the parasite that causes African tr

Synthesis and conformational analysis of tetrahydroisoquinoline- and piperidine-fused 1,3,4,2-oxadiazaphosphinanes, new ring systems

Through cyclization of tetrahydroisoquinoline and piperidine 1,2-hydrazino alcohols with phenylphosphonic dichloride and phenyl dichlorophosphate, P-epimeric diastereomers of 1,6,7,11b-tetrahydro-4H-1,3,4,2-oxadiazaphosphino[5, 4-a]isoquinoline-3-oxides (

Development of the Pictet-Spengler reaction catalyzed by AuCl 3/AgOTf

Mild and efficient AuCl3/AgOTf-catalyzed Pictet-Spengler reactions were developed to afford in good yields a variety of tetrahydroisoquinoline and tetrahydro-β-carboline ring systems, which constitute important motifs in biologically active nat