42052-44-8Relevant academic research and scientific papers
Synthesis and reactivity of imide-derived bisvinyl phosphates. Reactivity of 2,6-disubstituted 1,4-dihydropyridines
Mousset, Deborah,Gillaizeau, Isabelle,Sabatie, Andrea,Bouyssou, Pascal,Coudert, Gerard
, p. 5993 - 5999 (2007/10/03)
Symmetrical and unsymmetrical 2,6-disubstituted dihydropyridines were prepared in high yields under mild conditions using the Suzuki and Stille Pd-catalyzed coupling reactions of imide-derived bisvinyl phosphates with a range of aryl, heteroaryl, and alkenyl moieties. The alkylation reaction at C-4 easily afforded original tri- and tetrasubstituted dihydropyridines. Hydrolysis of the latter under acidic condition provided efficiently either open-chain 1,5-diketones or di- or trisubstituted pyridines.
Mechanism-based design of simple, symmetrical, easily prepared, potent antimalarial endoperoxides
Posner, Gary H.,Wang, Dasong,Gonzalez, Lluisa,Tao, Xueliang,Cumming, Jared N.,Klinedinst, Donna,Shapiro, Theresa A.
, p. 815 - 818 (2007/10/03)
Mechanism-based design, two-step synthesis, and in vitro antimalarial testing showed thermally stable, crystalline, bicyclic endoperoxides 2a and 2b to be potent antimalarials. Their reduction by FeBr2 proceeds via oxy-radicals and then carbon
Structure and Stereochemistry of the Dehydrobromination of some β-Bromo Ketones Derived from Alkyl Phenyl Ketones and Benzaldehyde
Quast, Helmut,Mueller, Bodo,Peters, Karl,Schnering, Hans Georg von
, p. 1525 - 1546 (2007/10/02)
The aldol reaction of alkyl phenyl ketones with benzaldehyde in the presence of hydrogen bromide affords diastereomeric β-bromo ketones under thermodynamic control.Thus, from propiophenone (8a) two diastereomeres 9a are obtained in a 67 : 33 ratio, while
