420786-61-4

Basic information

• Product Name: Ethyl 2-(4-forMyl-2-nitrophenoxy)acetate
• Synonyms: Ethyl 2-(4-forMyl-2-nitrophenoxy)acetate;2-(4-formyl-2-nitrophenoxy)acetic acid ethyl ester;2-(4-formyl-2-nitro-phenoxy)acetic acid ethyl ester;ethyl (4-formyl-2-nitrophenoxy)acetate;ethyl 2-(4-methanoyl-2-nitro-phenoxy)ethanoate
• CAS NO: 420786-61-4
• Molecular Formula: C₁₁H₁₁NO₆
• Molecular Weight: 253.20814
• Mol File: 420786-61-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 406.8±35.0 °C(Predicted)
• Appearance: /
• Density: 1.333±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl 2-(4-forMyl-2-nitrophenoxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-(4-forMyl-2-nitrophenoxy)acetate(420786-61-4)
• EPA Substance Registry System: Ethyl 2-(4-forMyl-2-nitrophenoxy)acetate(420786-61-4)

Safety Data

• Hazardous Substances Data: 420786-61-4(Hazardous Substances Data)

Usage

Description

Ethyl 2-(4-formyl-2-nitrophenoxy)acetate is a chemical compound with the molecular formula C11H11NO6. It is classified as an ester and is derived from the reaction of ethyl acetate with 4-formyl-2-nitrophenol. This yellow crystalline solid is soluble in organic solvents and has a melting point of around 100-102°C.

Uses

Used in Organic Synthesis:
Ethyl 2-(4-formyl-2-nitrophenoxy)acetate is used as an intermediate in organic synthesis for the production of various chemical compounds.
Used in Pharmaceutical Production:
Ethyl 2-(4-forMyl-2-nitrophenoxy)acetate is used as a precursor in the production of pharmaceuticals due to its potential applications in drug development.
Used in Agrochemical Production:
This ester is also utilized as a precursor in the production of agrochemicals, contributing to the development of pesticides and other agricultural products.
Used in Antimicrobial Applications:
Ethyl 2-(4-formyl-2-nitrophenoxy)acetate exhibits antimicrobial properties, making it a potential candidate for the development of new antimicrobial agents.
Used in Anti-inflammatory Applications:
Due to its anti-inflammatory properties, Ethyl 2-(4-forMyl-2-nitrophenoxy)acetate is considered for the development of new anti-inflammatory drugs, which could be beneficial in treating various inflammatory conditions.

Upstream product

• 3011-34-5 4-hydroxy-3-nitrobenzaldehyde 
• 105-39-5 chloroacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 615568-17-7 6-hydroxymethyl-4H-benzo[1,4]oxazin-3-one 
• 200195-15-9 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde 

Relevant articles and documents

ANTI-FIBROTIC COMPOUNDS

Provided herein are anti-fibrotic compounds, in particular those of Formula (I), that inhibit the TGF-beta signaling pathway. Also provided are pharmaceutical compositions comprising the anti-fibrotic compounds, and methods of treating diseases or conditions associated with fibrosis, inflammation, and benign or malignant neoplastic diseases in a subject by administering a compound or composition described herein. (Formula (I))

HYPOPHOSPHOROUS ACID DERIVATIVES HAVING ANTIHYPERALGIC ACTIVITY AND BIOLOGICAL APPLICATIONS THEREOF

The invention relates to hypophosphorous acid derivatives of formula (I) wherein - X is H or OH, - R represents one or several radicals R1-R5, identical or different, two of R1-R5 optionally occupying the same position on the phenyl group, one to four of R1-R5 being H and the others being selected in the group comprising - 0-(CH2)n-COOH; - S-(CH2)n-COOH; -NH-(CH2)n-COOH; - 0-(CH,R') -COOH; -O- (CH2)n-OH; OR', -R' being a C1 -C3 alkyl radical;-OH; --COOH; halogen, particularly -F, - CI, -Br, -I, -CF3; -OCF3; -N02; -CH=CH-COOH; - -(CH2)n-COOH; O - (CH2)n- P03H2; O - (CF2)n- P03H2; O - (CH2)n- S03H; O - (CH2)n- CONHOH; O - (CH2)n-tetrazol; O - (CH2)n-hydroxyisoxazol - n = 1 to 5, preferably 1-3; said hypophosrous acid derivatives being diastereoisomers or enantiomers.

Design and synthesis of phenethyl benzo[1,4]oxazine-3-ones as potent inhibitors of PI3Kinaseγ

The Type 1 PI3Kinases comprise a family of enzymes, which primarily phosphorylate PIP2 to give the second messenger PIP3, a key player in many intracellular signaling processes [Science, 2002, 296, 1655; Trends Pharmacol. Sci. 2003, 24, 366]. Of the four type 1 PI3Ks, the γ-isoform, which is expressed almost exclusively in leukocytes [Curr. Biol., 1997, 7, R470], is of particular interest with respect to its role in inflammatory diseases such as rheumatoid arthritis (RA) and chronic obstructive pulmonary disease (COPD) [Mol. Med. Today, 2000, 6, 347]. Investigation of a series of 4,6-disubstituted-4H-benzo[1,4]oxazin-3-ones has led to the identification of single-digit nanomolar inhibitors of PI3Kγ, several of which had good cell based activity and were shown to be active in vivo in an aspectic peritonitis model of inflammatory cell migration.